Design: RG analysis was conducted by a multidisciplinary panel of patients, clinicians and researchers(n=71). Eight Working Groups (WGs) were constituted: Discovery Science; Risk; Prevention; Early diagnosis and Screening; Pathology; Curative treatment; Stage IV disease; Living With and Beyond CRC. A series of discussions led to development of draft papers by each WG, which were evaluated by a 20-strong patient panel. A final list of RGs and Research Recommendations (RRs) was endorsed by all participants.
Results: Fifteen Critical RGs are summarised below: RG1:Lack of realistic models that recapitulate tumour/tumour micro/macro-environment; RG2:Insufficient evidence on precise contributions of genetic/environmental/ lifestyle factors to CRC risk; RG3:Pressing need for prevention trials; RG4: Lack of integration of different prevention approaches; RG5:Lack of optimal strategies for CRC screening; RG6:Lack of effective triage systems for invasive investigations; RG7:Imprecise pathological assessment of CRC; RG8:Lack of qualified personnel in genomics, data sciences and digital pathology; RG9: Inadequate assessment/communication of risk, benefit and uncertainty of treatment choices; RG10:Need for novel technologies/interventions to improve curative outcomes; RG11:Lack of approaches that recognise molecular interplay between metastasising tumours and their microenvironment; RG12: Lack of reliable biomarkers to guide stage IV treatment RG13:Need to increase understanding of Health-Related-Quality-of-Life(HRQOL) and promote residual symptom resolution; RG14:Lack of coordination of CRC research/funding; RG15:Lack of effective communication between relevant stakeholders.
Conclusion: Prioritising research activity and funding could have a significant impact on reducing CRC disease burden over the next 5 years.
- colorectal cancer
- critical research gaps
- research prioritisation
- patient focus
- Genetic Predisposition to Disease
- Risk Factors
- Biomedical Research/methods
- Gene-Environment Interaction
- Colorectal Neoplasms/diagnosis
- Early Detection of Cancer/methods
- Evidence-Based Medicine/methods