TY - JOUR
T1 - Cross-kingdom comparison of the developmental hourglass
AU - Drost, Hajk-Georg
AU - Janitza, Philipp
AU - Grosse, Ivo
AU - Quint, Marcel
N1 - Publisher Copyright:
© 2017 The Authors
PY - 2017/8
Y1 - 2017/8
N2 - The developmental hourglass model has its foundations in classic anatomical studies by von Baer and Haeckel. In this context, even the conservation of animal body plans has been explained by evolutionary constraints acting on mid-embryogenic development. Recent studies have shown that developmental hourglass patterns also exist on the transcriptomic level, mirroring the corresponding morphological patterns. The identification of similar patterns in embryonic, post-embryonic, and life cycle spanning transcriptomes in plant and fungus development, however, contradict the notion of a direct coupling between morphological and molecular patterns. To explain the existence of hourglass patterns across kingdoms and developmental processes, we propose the organizational checkpoint model that integrates the developmental hourglass model into a framework of transcriptome switches.
AB - The developmental hourglass model has its foundations in classic anatomical studies by von Baer and Haeckel. In this context, even the conservation of animal body plans has been explained by evolutionary constraints acting on mid-embryogenic development. Recent studies have shown that developmental hourglass patterns also exist on the transcriptomic level, mirroring the corresponding morphological patterns. The identification of similar patterns in embryonic, post-embryonic, and life cycle spanning transcriptomes in plant and fungus development, however, contradict the notion of a direct coupling between morphological and molecular patterns. To explain the existence of hourglass patterns across kingdoms and developmental processes, we propose the organizational checkpoint model that integrates the developmental hourglass model into a framework of transcriptome switches.
UR - http://www.scopus.com/inward/record.url?scp=85016078397&partnerID=8YFLogxK
U2 - 10.1016/j.gde.2017.03.003
DO - 10.1016/j.gde.2017.03.003
M3 - Review article
C2 - 28347942
AN - SCOPUS:85016078397
SN - 0959-437X
VL - 45
SP - 69
EP - 75
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
ER -