Cross-kingdom comparison of the developmental hourglass

Hajk-Georg Drost; Philipp Janitza; Ivo Grosse; Marcel Quint

doi:10.1016/j.gde.2017.03.003

Cross-kingdom comparison of the developmental hourglass

Hajk-Georg Drost
, Philipp Janitza
, Ivo Grosse
, Marcel Quint (Lead / Corresponding author)

Computational Biology

Research output: Contribution to journal › Review article › peer-review

47 Citations (Scopus)

54 Downloads (Pure)

Abstract

The developmental hourglass model has its foundations in classic anatomical studies by von Baer and Haeckel. In this context, even the conservation of animal body plans has been explained by evolutionary constraints acting on mid-embryogenic development. Recent studies have shown that developmental hourglass patterns also exist on the transcriptomic level, mirroring the corresponding morphological patterns. The identification of similar patterns in embryonic, post-embryonic, and life cycle spanning transcriptomes in plant and fungus development, however, contradict the notion of a direct coupling between morphological and molecular patterns. To explain the existence of hourglass patterns across kingdoms and developmental processes, we propose the organizational checkpoint model that integrates the developmental hourglass model into a framework of transcriptome switches.

Original language	English
Pages (from-to)	69-75
Number of pages	7
Journal	Current Opinion in Genetics and Development
Volume	45
Early online date	24 Mar 2017
DOIs	https://doi.org/10.1016/j.gde.2017.03.003
Publication status	Published - Aug 2017

ASJC Scopus subject areas

Genetics
Developmental Biology

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title = "Cross-kingdom comparison of the developmental hourglass",

abstract = "The developmental hourglass model has its foundations in classic anatomical studies by von Baer and Haeckel. In this context, even the conservation of animal body plans has been explained by evolutionary constraints acting on mid-embryogenic development. Recent studies have shown that developmental hourglass patterns also exist on the transcriptomic level, mirroring the corresponding morphological patterns. The identification of similar patterns in embryonic, post-embryonic, and life cycle spanning transcriptomes in plant and fungus development, however, contradict the notion of a direct coupling between morphological and molecular patterns. To explain the existence of hourglass patterns across kingdoms and developmental processes, we propose the organizational checkpoint model that integrates the developmental hourglass model into a framework of transcriptome switches.",

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AU - Drost, Hajk-Georg

AU - Janitza, Philipp

AU - Grosse, Ivo

AU - Quint, Marcel

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N2 - The developmental hourglass model has its foundations in classic anatomical studies by von Baer and Haeckel. In this context, even the conservation of animal body plans has been explained by evolutionary constraints acting on mid-embryogenic development. Recent studies have shown that developmental hourglass patterns also exist on the transcriptomic level, mirroring the corresponding morphological patterns. The identification of similar patterns in embryonic, post-embryonic, and life cycle spanning transcriptomes in plant and fungus development, however, contradict the notion of a direct coupling between morphological and molecular patterns. To explain the existence of hourglass patterns across kingdoms and developmental processes, we propose the organizational checkpoint model that integrates the developmental hourglass model into a framework of transcriptome switches.

AB - The developmental hourglass model has its foundations in classic anatomical studies by von Baer and Haeckel. In this context, even the conservation of animal body plans has been explained by evolutionary constraints acting on mid-embryogenic development. Recent studies have shown that developmental hourglass patterns also exist on the transcriptomic level, mirroring the corresponding morphological patterns. The identification of similar patterns in embryonic, post-embryonic, and life cycle spanning transcriptomes in plant and fungus development, however, contradict the notion of a direct coupling between morphological and molecular patterns. To explain the existence of hourglass patterns across kingdoms and developmental processes, we propose the organizational checkpoint model that integrates the developmental hourglass model into a framework of transcriptome switches.

UR - https://www.scopus.com/pages/publications/85016078397

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DO - 10.1016/j.gde.2017.03.003

M3 - Review article

C2 - 28347942

AN - SCOPUS:85016078397

SN - 0959-437X

VL - 45

SP - 69

EP - 75

JO - Current Opinion in Genetics and Development

JF - Current Opinion in Genetics and Development

ER -

Cross-kingdom comparison of the developmental hourglass

Abstract

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