Cross-talk between the p38 alpha and JNK MAPK Pathways Mediated by MAP Kinase Phosphatase-1 Determines Cellular Sensitivity to UV Radiation

Keyphrases

• Mitogen-activated Protein Kinase 100%
• Cellular Sensitivity 100%
• DUSP1 100%
• MAP Kinase Phosphatase 100%
• P38α 100%
• UV Radiation 100%
• JNK MAPK 100%
• MKP-1 91%
• UV-induced 25%
• Mouse Embryonic Fibroblasts 25%
• Cell Death 16%
• Knockdown 16%
• JNK1 16%
• Cisplatin 8%
• Small Interfering RNA (siRNA) 8%
• Ionizing Radiation 8%
• CAMP Response Element-binding Protein 8%
• Mitogen 8%
• Mammalian Cells 8%
• MSK1 8%
• Cellular Response 8%
• ERK2 8%
• ATF1 8%
• Induced Apoptosis 8%
• Wild Mice 8%
• Cell Survival 8%
• Null Mice 8%
• Hydrogen Peroxide 8%
• Induced Cell Death 8%
• JNK Pathway 8%
• RNA-based 8%
• Lethality 8%
• Insults 8%
• Stress-inducible 8%
• JNK2 8%
• Downstream Effectors 8%
• Reintroduction 8%
• Cellular Protection 8%
• Pharmacological Tools 8%
• Genetic Tools 8%

Biochemistry, Genetics and Molecular Biology

• Mitogen-Activated Protein Kinase 100%
• MAP Kinase Phosphatase 100%
• DUSP1 100%
• Cell Death 30%
• Fibroblast 30%
• Wild Type 10%
• Genetics 10%
• Cyclic Adenosine Monophosphate 10%
• Transcription 10%
• Small Interfering RNA 10%
• Mediator 10%
• Phosphoprotein Phosphatase 10%
• Binding Protein 10%
• Response Element 10%
• Knockout Mouse 10%
• Wild Type Mouse 10%
• Cell Survival 10%
• Hydrogen Peroxide 10%
• Cisplatin 10%
• MAPK Phosphatase 10%
• Activating Transcription Factor 1 10%
• Messenger RNA 10%
• Programmed Cell Death 10%