Crystal structures of Burkholderia cenocepacia dihydropteroate synthase in the apo-form and complexed with the product 7,8-dihydropteroate

Keyphrases

• Apo Form 100%
• Dihydropteroate Synthase 100%
• Burkholderia Cenocepacia 100%
• Active Sites 37%
• Orthologues 25%
• Folate 25%
• Angstrom 25%
• Burkholderia 25%
• Drug Discovery 12%
• Condensation 12%
• Complex Structure 12%
• New Drugs 12%
• Binding Site 12%
• Sequence Identity 12%
• Gram-negative Bacteria 12%
• Ligand Binding 12%
• Structural Information 12%
• Product Complexity 12%
• Antibiotics 12%
• Pterin 12%
• Hit Discovery 12%
• Cystic Fibrosis 12%
• Therapeutic Target 12%
• Conformational States 12%
• Crystal Form 12%
• Infectious Agents 12%
• Loop Conformation 12%
• Hydroxymethyl 12%
• Protein Expression System 12%
• Apoenzyme 12%
• Orthorhombic Crystal 12%
• Gram-negative Pathogens 12%
• Antimicrobial Therapeutics 12%
• Pyrophosphate 12%
• Ligand Recognition 12%
• Ligand Complexes 12%
• Cenocepacia 12%
• Opportunistic Pathogens 12%
• 4-aminobenzoic Acid 12%
• Substrate-binding Pocket 12%
• Sulfinamides 12%
• Active Interaction 12%
• Enzyme Product 12%
• Recombinant Protein Production 12%
• Gram-negative 12%

Biochemistry, Genetics and Molecular Biology

• Crystal Structure 100%
• Burkholderia cenocepacia 100%
• Dihydropteroate Synthase 100%
• Enzyme 75%
• Active Site 37%
• Infectious Agent 25%
• Burkholderia 25%
• Genetics 12%
• Binding Site 12%
• Protein Expression 12%
• Conformation 12%
• Ligand Binding 12%
• DNA Template 12%
• Recombinant Protein 12%
• Cystic Fibrosis 12%
• Gene Expression System 12%
• Folic Acid 12%
• Gram Negative Bacterium 12%
• Pyrophosphate 12%
• Sulfenamide 12%