Crystal structures of IspF from Plasmodium falciparum and Burkholderia cenocepacia: comparisons inform antimicrobial drug target assessment

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• Finished

  A Translational Engine for Biomedical Discoveries (Strategic Grant)

  Fairlamb, A. (Investigator) & Gilbert, I. (Investigator)

  1/01/13 → 30/09/15

  Project: Research

  • Proteolysis Targeting chimera (PROTAC) 100%
  • Protein Catabolism 87%
  • Visceral Leishmaniasis 73%
  • Trypanosoma Brucei 67%
  • Ubiquitin-Conjugating Enzyme 64%

• State-of-the-Art Facilities for Structural Biology at the University of Dundee

  Hunter, B. (Investigator), Lilley, D. (Investigator), Owen-Hughes, T. (Investigator), Wyatt, P. (Investigator) & van Aalten, D. (Investigator)

  1/03/12 → 28/02/17

  Project: Research

  • Proteolysis Targeting chimera (PROTAC) 100%
  • Crystal Structure 82%
  • Protein Catabolism 71%
  • Enzyme 70%
  • Ligase 60%

• Aref#d: 19401. Structure, specificity and mechanism of biosynthetic enzymes in trypanosomatids and inhibitor discovery of essential microbial functions (Programme Grant)

  Hunter, B. (Investigator)

  1/11/07 → 31/12/13

  Project: Research

  • Enzyme 100%
  • Crystal Structure 87%
  • Trypanosoma Brucei 69%
  • Active Sites 67%
  • Active Site 57%