Crystallographic study of inhibitors of tRNA-guanine transglycosylase suggests a new structure-based pharmacophore for virtual screening

Ruth Brenk; Emmanuel A. Meyer; Klaus Reuter; Milton T. Stubbs; George A. Garcia; François Diederich; Gerhard Klebe

doi:10.1016/j.jmb.2004.02.019

Crystallographic study of inhibitors of tRNA-guanine transglycosylase suggests a new structure-based pharmacophore for virtual screening

Ruth Brenk
, Emmanuel A. Meyer
, Klaus Reuter
, Milton T. Stubbs
, George A. Garcia
, François Diederich
, Gerhard Klebe

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	55-75
Number of pages	21
Journal	Journal of Molecular Biology
Volume	338
Issue number	1
DOIs	https://doi.org/10.1016/j.jmb.2004.02.019
Publication status	Published - Apr 2004

Keywords

TGT
Crystallography
Inhibitors
Ligands

Access to Document

10.1016/j.jmb.2004.02.019

Cite this

@article{386f34e991604af58224e649af3b9c52,

title = "Crystallographic study of inhibitors of tRNA-guanine transglycosylase suggests a new structure-based pharmacophore for virtual screening",

keywords = "TGT, Crystallography, Inhibitors, Ligands",

author = "Ruth Brenk and Meyer, \{Emmanuel A.\} and Klaus Reuter and Stubbs, \{Milton T.\} and Garcia, \{George A.\} and Fran{\c c}ois Diederich and Gerhard Klebe",

note = " dc.publisher: Elsevier dc.description.sponsorship: Deutsche Forschungsgemeinschaft Grant KL-1204/1 ETH Research Council ",

year = "2004",

month = apr,

doi = "10.1016/j.jmb.2004.02.019",

language = "English",

volume = "338",

pages = "55--75",

journal = "Journal of Molecular Biology",

issn = "0022-2836",

publisher = "Academic Press",

number = "1",

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TY - JOUR

T1 - Crystallographic study of inhibitors of tRNA-guanine transglycosylase suggests a new structure-based pharmacophore for virtual screening

AU - Brenk, Ruth

AU - Meyer, Emmanuel A.

AU - Reuter, Klaus

AU - Stubbs, Milton T.

AU - Garcia, George A.

AU - Diederich, François

AU - Klebe, Gerhard

N1 - dc.publisher: Elsevier dc.description.sponsorship: Deutsche Forschungsgemeinschaft Grant KL-1204/1 ETH Research Council

PY - 2004/4

Y1 - 2004/4

KW - TGT

KW - Crystallography

KW - Inhibitors

KW - Ligands

U2 - 10.1016/j.jmb.2004.02.019

DO - 10.1016/j.jmb.2004.02.019

M3 - Article

C2 - 15050823

SN - 0022-2836

VL - 338

SP - 55

EP - 75

JO - Journal of Molecular Biology

JF - Journal of Molecular Biology

IS - 1

ER -