TY - JOUR
T1 - CSF metabolic and proteomic profiles in patients prodromal for psychosis
AU - Huang, Jeffrey T.
AU - Leweke, F. Markus
AU - Tsang, Tsz M.
AU - Koethe, Dagmar
AU - Kranaster, Laura
AU - Gerth, Christoph W.
AU - Gross, Sonja
AU - Schreiber, Daniela
AU - Ruhrmann, Stephan
AU - Schutlze-Lutter, Frauke
AU - Klosterkötter, Joachim
AU - Holmes, Elaine
AU - Bahn, Sabine
N1 - Funding: This research was supported by the Stanley Medical Research Institute (SMRI) and the Koeln Fortune Program. Further thanks to The Henry Smith Charity and the BBSRC for financial support. S.B. holds a NARSAD Essel Independent Investigator Fellowship.
PY - 2007/8/22
Y1 - 2007/8/22
N2 - Background: The initial prodromal state of psychosis (IPS) is defined as an early disease stage prior to the onset of overt psychosis characterized by sub-threshold or more unspecific psychiatric symptoms. Little is known regarding the biochemical changes during this period. Methodology/Principal Findings: We investigated the metabolic/proteomic profiles of cerebrospinal fluid (CSF) of first onset drug naïve paranoid schizophrenía patients (n=54) and individuals presenting with initial prodromal symptoms (n=24), alongside healthy volunteers (n=70) using proton nuclear magnetic resonance (1H-NMR) spectroscopy and surface enhanced laser desorption ionization (SELDI) mass spectrometry, respectively. Partial least square discriminant analysis (PLS-DA) showed that 36%/29% of IPS patients displayed proteomic/metabolic profiles characteristic of first-onset, drug naïve schizophrenia, i.e., changes in levels of glucose and lactate as well as changes in a VGF-derived peptide (VGF23-62) and transthyretin protein concentrations. However, only 29% (n=7) of the investigated IPS patients (who to date have been followed up for up to three years) have so far received a diagnosis of schizophrenia, The presence of biochemical alterations in the IPS group did not correlate with the risk to develop schizophrenia. Conclusions/Significance: Our results imply that schizophrenia-related biochemical disease processes can be traced in CSF of prodromal patients. However, the biochemical disturbances identified in IPS patients, at least when measured at a single time point, may not be sufficient to predict clinical outcome.
AB - Background: The initial prodromal state of psychosis (IPS) is defined as an early disease stage prior to the onset of overt psychosis characterized by sub-threshold or more unspecific psychiatric symptoms. Little is known regarding the biochemical changes during this period. Methodology/Principal Findings: We investigated the metabolic/proteomic profiles of cerebrospinal fluid (CSF) of first onset drug naïve paranoid schizophrenía patients (n=54) and individuals presenting with initial prodromal symptoms (n=24), alongside healthy volunteers (n=70) using proton nuclear magnetic resonance (1H-NMR) spectroscopy and surface enhanced laser desorption ionization (SELDI) mass spectrometry, respectively. Partial least square discriminant analysis (PLS-DA) showed that 36%/29% of IPS patients displayed proteomic/metabolic profiles characteristic of first-onset, drug naïve schizophrenia, i.e., changes in levels of glucose and lactate as well as changes in a VGF-derived peptide (VGF23-62) and transthyretin protein concentrations. However, only 29% (n=7) of the investigated IPS patients (who to date have been followed up for up to three years) have so far received a diagnosis of schizophrenia, The presence of biochemical alterations in the IPS group did not correlate with the risk to develop schizophrenia. Conclusions/Significance: Our results imply that schizophrenia-related biochemical disease processes can be traced in CSF of prodromal patients. However, the biochemical disturbances identified in IPS patients, at least when measured at a single time point, may not be sufficient to predict clinical outcome.
U2 - 10.1371/journal.pone.0000756
DO - 10.1371/journal.pone.0000756
M3 - Article
C2 - 17712404
AN - SCOPUS:39749171224
VL - 2
SP - 1
EP - 7
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 8
M1 - e756
ER -