CSF metabolic and proteomic profiles in patients prodromal for psychosis

Jeffrey T. Huang, F. Markus Leweke, Tsz M. Tsang, Dagmar Koethe, Laura Kranaster, Christoph W. Gerth, Sonja Gross, Daniela Schreiber, Stephan Ruhrmann, Frauke Schutlze-Lutter, Joachim Klosterkötter, Elaine Holmes, Sabine Bahn

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    Abstract

    Background: The initial prodromal state of psychosis (IPS) is defined as an early disease stage prior to the onset of overt psychosis characterized by sub-threshold or more unspecific psychiatric symptoms. Little is known regarding the biochemical changes during this period. Methodology/Principal Findings: We investigated the metabolic/proteomic profiles of cerebrospinal fluid (CSF) of first onset drug naïve paranoid schizophrenía patients (n=54) and individuals presenting with initial prodromal symptoms (n=24), alongside healthy volunteers (n=70) using proton nuclear magnetic resonance (1H-NMR) spectroscopy and surface enhanced laser desorption ionization (SELDI) mass spectrometry, respectively. Partial least square discriminant analysis (PLS-DA) showed that 36%/29% of IPS patients displayed proteomic/metabolic profiles characteristic of first-onset, drug naïve schizophrenia, i.e., changes in levels of glucose and lactate as well as changes in a VGF-derived peptide (VGF23-62) and transthyretin protein concentrations. However, only 29% (n=7) of the investigated IPS patients (who to date have been followed up for up to three years) have so far received a diagnosis of schizophrenia, The presence of biochemical alterations in the IPS group did not correlate with the risk to develop schizophrenia. Conclusions/Significance: Our results imply that schizophrenia-related biochemical disease processes can be traced in CSF of prodromal patients. However, the biochemical disturbances identified in IPS patients, at least when measured at a single time point, may not be sufficient to predict clinical outcome.

    Original languageEnglish
    Article numbere756
    Pages (from-to)1-7
    Number of pages7
    JournalPLoS ONE
    Volume2
    Issue number8
    DOIs
    Publication statusPublished - 22 Aug 2007

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  • Cite this

    Huang, J. T., Leweke, F. M., Tsang, T. M., Koethe, D., Kranaster, L., Gerth, C. W., Gross, S., Schreiber, D., Ruhrmann, S., Schutlze-Lutter, F., Klosterkötter, J., Holmes, E., & Bahn, S. (2007). CSF metabolic and proteomic profiles in patients prodromal for psychosis. PLoS ONE, 2(8), 1-7. [e756]. https://doi.org/10.1371/journal.pone.0000756