Curcumin and the cellular stress response in free radical-related diseases

Vittorio Calabrese, Timothy E. Bates, Cesare Mancuso, Carolin Cornelius, Bernardo Ventimiglia, Maria Teresa Cambria, Laura Di Renzo, Antonino De Lorenzo, Albena T. Dinkova-Kostova

    Research output: Contribution to journalReview article

    112 Citations (Scopus)

    Abstract

    Free radicals play a main pathogenic role in several human diseases such as neurodegenerative disorders, diabetes, and cancer. Although there has been progress in treatment of these diseases, the development of important side effects may complicate the therapeutic course. Curcumin, a well known spice commonly used in India to make foods colored and flavored, is also used in traditional medicine to treat mild or moderate human diseases. In the recent years, a growing body of literature has unraveled the antioxidant, anticarcinogenic, and antinfectious activity of curcumin based on the ability of this compound to regulate a number of cellular signal transduction pathways. These promising data obtained in vitro are now being translated to the clinic and more than ten clinical trials are currently ongoing worldwide. This review outlines the biological activities of curcumin and discusses its potential use in the prevention and treatment of human diseases.

    Original languageEnglish
    Pages (from-to)1062-1073
    Number of pages12
    JournalMolecular Nutrition & Food Research
    Volume52
    Issue number9
    DOIs
    Publication statusPublished - Sep 2008

    Keywords

    • curcumin
    • free radicals
    • heat shock proteins
    • heme oxygenase
    • neurodegenerative disorders
    • NF-KAPPA-B
    • UNFOLDED PROTEIN RESPONSE
    • AMYLOID-BETA-PEPTIDE
    • CHEMOPREVENTIVE AGENT CURCUMIN
    • COLORECTAL-CARCINOMA CELLS
    • CENTRAL-NERVOUS-SYSTEM
    • HSP70 GENE-EXPRESSION
    • I CLINICAL-TRIAL
    • OXIDATIVE STRESS
    • NITRIC-OXIDE

    Cite this

    Calabrese, V., Bates, T. E., Mancuso, C., Cornelius, C., Ventimiglia, B., Cambria, M. T., Di Renzo, L., De Lorenzo, A., & Dinkova-Kostova, A. T. (2008). Curcumin and the cellular stress response in free radical-related diseases. Molecular Nutrition & Food Research, 52(9), 1062-1073. https://doi.org/10.1002/mnfr.200700316