Curcumin and the cellular stress response in free radical-related diseases

Vittorio Calabrese; Timothy E. Bates; Cesare Mancuso; Carolin Cornelius; Bernardo Ventimiglia; Maria Teresa Cambria; Laura Di Renzo; Antonino De Lorenzo; Albena T. Dinkova-Kostova

doi:10.1002/mnfr.200700316

Curcumin and the cellular stress response in free radical-related diseases

Vittorio Calabrese, Timothy E. Bates, Cesare Mancuso, Carolin Cornelius, Bernardo Ventimiglia, Maria Teresa Cambria, Laura Di Renzo, Antonino De Lorenzo, Albena T. Dinkova-Kostova

Research output: Contribution to journal › Review article › peer-review

149 Citations (Scopus)

Abstract

Free radicals play a main pathogenic role in several human diseases such as neurodegenerative disorders, diabetes, and cancer. Although there has been progress in treatment of these diseases, the development of important side effects may complicate the therapeutic course. Curcumin, a well known spice commonly used in India to make foods colored and flavored, is also used in traditional medicine to treat mild or moderate human diseases. In the recent years, a growing body of literature has unraveled the antioxidant, anticarcinogenic, and antinfectious activity of curcumin based on the ability of this compound to regulate a number of cellular signal transduction pathways. These promising data obtained in vitro are now being translated to the clinic and more than ten clinical trials are currently ongoing worldwide. This review outlines the biological activities of curcumin and discusses its potential use in the prevention and treatment of human diseases.

Original language	English
Pages (from-to)	1062-1073
Number of pages	12
Journal	Molecular Nutrition & Food Research
Volume	52
Issue number	9
DOIs	https://doi.org/10.1002/mnfr.200700316
Publication status	Published - Sept 2008

Keywords

curcumin
free radicals
heat shock proteins
heme oxygenase
neurodegenerative disorders
NF-KAPPA-B
UNFOLDED PROTEIN RESPONSE
AMYLOID-BETA-PEPTIDE
CHEMOPREVENTIVE AGENT CURCUMIN
COLORECTAL-CARCINOMA CELLS
CENTRAL-NERVOUS-SYSTEM
HSP70 GENE-EXPRESSION
I CLINICAL-TRIAL
OXIDATIVE STRESS
NITRIC-OXIDE

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/mnfr.200700316

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title = "Curcumin and the cellular stress response in free radical-related diseases",

abstract = "Free radicals play a main pathogenic role in several human diseases such as neurodegenerative disorders, diabetes, and cancer. Although there has been progress in treatment of these diseases, the development of important side effects may complicate the therapeutic course. Curcumin, a well known spice commonly used in India to make foods colored and flavored, is also used in traditional medicine to treat mild or moderate human diseases. In the recent years, a growing body of literature has unraveled the antioxidant, anticarcinogenic, and antinfectious activity of curcumin based on the ability of this compound to regulate a number of cellular signal transduction pathways. These promising data obtained in vitro are now being translated to the clinic and more than ten clinical trials are currently ongoing worldwide. This review outlines the biological activities of curcumin and discusses its potential use in the prevention and treatment of human diseases.",

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author = "Vittorio Calabrese and Bates, {Timothy E.} and Cesare Mancuso and Carolin Cornelius and Bernardo Ventimiglia and Cambria, {Maria Teresa} and {Di Renzo}, Laura and {De Lorenzo}, Antonino and Dinkova-Kostova, {Albena T.}",

year = "2008",

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doi = "10.1002/mnfr.200700316",

language = "English",

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AU - Calabrese, Vittorio

AU - Bates, Timothy E.

AU - Mancuso, Cesare

AU - Cornelius, Carolin

AU - Ventimiglia, Bernardo

AU - Cambria, Maria Teresa

AU - Di Renzo, Laura

AU - De Lorenzo, Antonino

AU - Dinkova-Kostova, Albena T.

PY - 2008/9

Y1 - 2008/9

N2 - Free radicals play a main pathogenic role in several human diseases such as neurodegenerative disorders, diabetes, and cancer. Although there has been progress in treatment of these diseases, the development of important side effects may complicate the therapeutic course. Curcumin, a well known spice commonly used in India to make foods colored and flavored, is also used in traditional medicine to treat mild or moderate human diseases. In the recent years, a growing body of literature has unraveled the antioxidant, anticarcinogenic, and antinfectious activity of curcumin based on the ability of this compound to regulate a number of cellular signal transduction pathways. These promising data obtained in vitro are now being translated to the clinic and more than ten clinical trials are currently ongoing worldwide. This review outlines the biological activities of curcumin and discusses its potential use in the prevention and treatment of human diseases.

AB - Free radicals play a main pathogenic role in several human diseases such as neurodegenerative disorders, diabetes, and cancer. Although there has been progress in treatment of these diseases, the development of important side effects may complicate the therapeutic course. Curcumin, a well known spice commonly used in India to make foods colored and flavored, is also used in traditional medicine to treat mild or moderate human diseases. In the recent years, a growing body of literature has unraveled the antioxidant, anticarcinogenic, and antinfectious activity of curcumin based on the ability of this compound to regulate a number of cellular signal transduction pathways. These promising data obtained in vitro are now being translated to the clinic and more than ten clinical trials are currently ongoing worldwide. This review outlines the biological activities of curcumin and discusses its potential use in the prevention and treatment of human diseases.

KW - curcumin

KW - free radicals

KW - heat shock proteins

KW - heme oxygenase

KW - neurodegenerative disorders

KW - NF-KAPPA-B

KW - UNFOLDED PROTEIN RESPONSE

KW - AMYLOID-BETA-PEPTIDE

KW - CHEMOPREVENTIVE AGENT CURCUMIN

KW - COLORECTAL-CARCINOMA CELLS

KW - CENTRAL-NERVOUS-SYSTEM

KW - HSP70 GENE-EXPRESSION

KW - I CLINICAL-TRIAL

KW - OXIDATIVE STRESS

KW - NITRIC-OXIDE

U2 - 10.1002/mnfr.200700316

DO - 10.1002/mnfr.200700316

M3 - Review article

C2 - 18792015

SN - 1613-4125

VL - 52

SP - 1062

EP - 1073

JO - Molecular Nutrition & Food Research

JF - Molecular Nutrition & Food Research

IS - 9

ER -

Curcumin and the cellular stress response in free radical-related diseases

Abstract

Keywords

UN SDGs

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