Current and Future Perspectives for Improving Ovarian Tissue Cryopreservation and Transplantation Outcomes for Cancer Patients

Sanghoon Lee (Lead / Corresponding author), Sinan Ozkavukcu, Seung-Yup Ku

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)
36 Downloads (Pure)

Abstract

Although advances in cancer treatment and early diagnosis have significantly improved cancer survival rates, cancer therapies can cause serious side effects, including ovarian failure and infertility, in women of reproductive age. Infertility following cancer treatment can have significant adverse effects on the quality of life. However, established methods for fertility preservation, including embryo or oocyte cryopreservation, are not always suitable for female cancer patients because of complicated individual conditions and treatment methods. Ovarian tissue cryopreservation and transplantation is a promising option for fertility preservation in pre-pubertal girls and adult patients with cancer who require immediate treatment, or who are not eligible to undergo ovarian stimulation. This review introduces various methods and strategies to improve ovarian tissue cryopreservation and transplantation outcomes, to help patients and clinicians choose the best option when considering the potential complexity of a patient’s situation. Effective multidisciplinary oncofertility strategies, involving the inclusion of a highly skilled and experienced oncofertility team that considers cryopreservation methods, thawing processes and devices, surgical procedures for transplantation, and advances in technologies, are necessary to provide high-quality care to a cancer patient.

Original languageEnglish
Pages (from-to)1746-1758
Number of pages13
JournalReproductive Sciences
Volume28
Issue number6
Early online date31 Mar 2021
DOIs
Publication statusPublished - 1 Jun 2021

Keywords

  • Fertility preservation
  • Ovarian freezing
  • Autologous transplantation
  • Cancer treatment
  • Oncofertility
  • Primary ovarian insufficiency

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