Current concepts in assessment of microvascular endothelial function using laser Doppler imaging and iontophoresis

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    Abstract

    Effective evaluation of endothelial function is a powerful tool for determining patients at risk of development and progression of cardiovascular disease. As an alternative to invasive tests of endothelial function, several noninvasive methods have been developed, including the use of laser Doppler flowmetry/imaging to measure cutaneous perfusion accompanied by iontophoresis of acetylcholine and sodium nitroprusside. It is clear from previous studies that this technique provides an easy, validated, and reproducible method for investigators to assess and monitor endothelial function in patients with a variety of pathologic conditions, but it may also be used to examine disease progression over time and responsiveness to treatment, thereby facilitating clinical trials. However, a standardization of protocols would help reduce the apparent controversy seen in the literature. With its increasing use by other groups, it is anticipated that further published studies will help to provide a better understanding of the development and progression of cardiovascular disease.

    Original languageEnglish
    Pages (from-to)109-116
    Number of pages8
    JournalTrends in Cardiovascular Medicine
    Volume18
    Issue number4
    Publication statusPublished - May 2008

    Keywords

    • SKIN BLOOD-FLOW
    • ASPIRIN-SENSITIVE MECHANISMS
    • NONINVASIVE ASSESSMENT
    • SODIUM-NITROPRUSSIDE
    • NITRIC-OXIDE
    • WATER IONTOPHORESIS
    • YOUNG-PATIENTS
    • ACETYLCHOLINE
    • DYSFUNCTION
    • MICROCIRCULATION

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