Current management and treatment of cerebral vasospasm complicating SAH

Anna Luisa Kühn, Joyce Saleh Balami, Iris Quasar Grunwald (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

Abstract

Cerebral vasospasm is a common and serious complication of aneurysmal subarachnoid haemorrhage. Despite the improvements in treatment of aneurysmal subarachnoid haemorrhage (aSAH), cerebral vasospasm complicating aSAH has remained the main cause of morbidity and mortality. Subarachnoid haemorrhage (SAH)-induced vasospasm is a complex entity caused by vasculopathy, impaired autoregulation, and hypovolaemia, causing a regional reduction of cerebral brain perfusion which can then induce ischaemia. Cerebral vasospasm can present either asymptomatically detected only radiologically or symptomatically (delayed ischaemic neurologic deficit). The various diagnostic approaches include the use of transcranial doppler, digital subtraction angiography and multimodal computed tomography (CT) and magnetic resonance (MR) techniques. Although digital subtraction angiography is usually the gold standard for the diagnosis of cerebral vasospam, transcranial doppler is commonly the first-screening method for the detection of cerebral vasospam. The treatment of subarachnoid haemorrhage -induced vasospasm include the use of both medical and endovascular therapy. The aim of this review is to discuss the various current therapeutic options and future perspective measures for reducing cerebral vasospasm induced stroke after SAH.

Original languageEnglish
Pages (from-to)233-241
Number of pages9
JournalCNS & neurological disorders drug targets
Volume12
Issue number2
DOIs
Publication statusPublished - Mar 2013

Keywords

  • Humans
  • Magnetic Resonance Imaging
  • Subarachnoid Hemorrhage/complications
  • Tomography, X-Ray Computed
  • Vasospasm, Intracranial/diagnosis

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