CXCL-8-dependent and -independent neutrophil activation in COPD: experiences from a pilot study of the CXCR2 antagonist danirixin

Holly R. Keir, Hollian Richardson, Christina Fillmore, Amelia Shoemark, Aili L. Lazaar, Bruce E. Miller, Ruth Tal-Singer, James D. Chalmers (Lead / Corresponding author), Divya Mohan

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Abstract

The implications of these findings are significant for development of CXCR2 antagonists and other mechanisms targeting neutrophil activation or NETosis, suggesting that IL-8-dependent mechanisms will only work in a subset of COPD patients https://bit.ly/32SeisO.

Original languageEnglish
Article number00583-2020
Number of pages4
JournalERJ Open Research
Volume6
Issue number4
DOIs
Publication statusPublished - 10 Nov 2020

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