CXCL-8-dependent and -independent neutrophil activation in COPD: experiences from a pilot study of the CXCR2 antagonist danirixin

Holly R. Keir, Hollian Richardson, Christina Fillmore, Amelia Shoemark, Aili L. Lazaar, Bruce E. Miller, Ruth Tal-Singer, James D. Chalmers (Lead / Corresponding author), Divya Mohan

    Research output: Contribution to journalArticlepeer-review

    21 Citations (Scopus)
    56 Downloads (Pure)

    Abstract

    The implications of these findings are significant for development of CXCR2 antagonists and other mechanisms targeting neutrophil activation or NETosis, suggesting that IL-8-dependent mechanisms will only work in a subset of COPD patients https://bit.ly/32SeisO.

    Original languageEnglish
    Article number00583-2020
    Number of pages4
    JournalERJ Open Research
    Volume6
    Issue number4
    DOIs
    Publication statusPublished - 10 Nov 2020

    Fingerprint

    Dive into the research topics of 'CXCL-8-dependent and -independent neutrophil activation in COPD: experiences from a pilot study of the CXCR2 antagonist danirixin'. Together they form a unique fingerprint.

    Cite this