CXCL-8-dependent and -independent neutrophil activation in COPD: experiences from a pilot study of the CXCR2 antagonist danirixin

Holly R. Keir; Hollian Richardson; Christina Fillmore; Amelia Shoemark; Aili L. Lazaar; Bruce E. Miller; Ruth Tal-Singer; James D. Chalmers; Divya Mohan

doi:10.1183/23120541.00583-2020

CXCL-8-dependent and -independent neutrophil activation in COPD: experiences from a pilot study of the CXCR2 antagonist danirixin

Holly R. Keir, Hollian Richardson, Christina Fillmore, Amelia Shoemark, Aili L. Lazaar, Bruce E. Miller, Ruth Tal-Singer, James D. Chalmers (Lead / Corresponding author), Divya Mohan

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Abstract

The implications of these findings are significant for development of CXCR2 antagonists and other mechanisms targeting neutrophil activation or NETosis, suggesting that IL-8-dependent mechanisms will only work in a subset of COPD patients https://bit.ly/32SeisO.

Original language	English
Article number	00583-2020
Number of pages	4
Journal	ERJ Open Research
Volume	6
Issue number	4
DOIs	https://doi.org/10.1183/23120541.00583-2020
Publication status	Published - 10 Nov 2020

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10.1183/23120541.00583-2020Licence: CC BY-NC

Final Published VersionFinal published version, 448 KBLicence: CC BY-NC

Neutrophil extracellular traps in chronic lung disease
Keir, H. R. (Author), Chalmers, J. (Supervisor) & Shoemark, A. (Supervisor), 2022
Student thesis: Doctoral Thesis › Doctor of Philosophy

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title = "CXCL-8-dependent and -independent neutrophil activation in COPD: experiences from a pilot study of the CXCR2 antagonist danirixin",

abstract = "The implications of these findings are significant for development of CXCR2 antagonists and other mechanisms targeting neutrophil activation or NETosis, suggesting that IL-8-dependent mechanisms will only work in a subset of COPD patients https://bit.ly/32SeisO.",

author = "Keir, {Holly R.} and Hollian Richardson and Christina Fillmore and Amelia Shoemark and Lazaar, {Aili L.} and Miller, {Bruce E.} and Ruth Tal-Singer and Chalmers, {James D.} and Divya Mohan",

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AU - Keir, Holly R.

AU - Richardson, Hollian

AU - Fillmore, Christina

AU - Shoemark, Amelia

AU - Lazaar, Aili L.

AU - Miller, Bruce E.

AU - Tal-Singer, Ruth

AU - Chalmers, James D.

AU - Mohan, Divya

N1 - Funding GSK 207551

PY - 2020/11/10

Y1 - 2020/11/10

N2 - The implications of these findings are significant for development of CXCR2 antagonists and other mechanisms targeting neutrophil activation or NETosis, suggesting that IL-8-dependent mechanisms will only work in a subset of COPD patients https://bit.ly/32SeisO.

AB - The implications of these findings are significant for development of CXCR2 antagonists and other mechanisms targeting neutrophil activation or NETosis, suggesting that IL-8-dependent mechanisms will only work in a subset of COPD patients https://bit.ly/32SeisO.

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DO - 10.1183/23120541.00583-2020

M3 - Article

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SN - 2312-0541

VL - 6

JO - ERJ Open Research

JF - ERJ Open Research

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ER -

CXCL-8-dependent and -independent neutrophil activation in COPD: experiences from a pilot study of the CXCR2 antagonist danirixin

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Student theses

Neutrophil extracellular traps in chronic lung disease

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