CXCL-8-dependent and -independent neutrophil activation in COPD: experiences from a pilot study of the CXCR2 antagonist danirixin

Holly R. Keir; Hollian Richardson; Christina Fillmore; Amelia Shoemark; Aili L. Lazaar; Bruce E. Miller; Ruth Tal-Singer; James D. Chalmers; Divya Mohan

doi:10.1183/23120541.00583-2020

CXCL-8-dependent and -independent neutrophil activation in COPD: experiences from a pilot study of the CXCR2 antagonist danirixin

Holly R. Keir
, Hollian Richardson
, Christina Fillmore
, Amelia Shoemark
, Aili L. Lazaar
, Bruce E. Miller
, Ruth Tal-Singer
, James D. Chalmers (Lead / Corresponding author)
, Divya Mohan

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

130 Downloads (Pure)

Abstract

The implications of these findings are significant for development of CXCR2 antagonists and other mechanisms targeting neutrophil activation or NETosis, suggesting that IL-8-dependent mechanisms will only work in a subset of COPD patients https://bit.ly/32SeisO.

Original language	English
Article number	00583-2020
Number of pages	4
Journal	ERJ Open Research
Volume	6
Issue number	4
DOIs	https://doi.org/10.1183/23120541.00583-2020
Publication status	Published - 10 Nov 2020

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10.1183/23120541.00583-2020Licence: CC BY-NC

Final Published VersionFinal published version, 448 KBLicence: CC BY-NC

Neutrophil extracellular traps in chronic lung disease
Keir, H. R. (Author), Chalmers, J. (Supervisor) & Shoemark, A. (Supervisor), 2022
Student thesis: Doctoral Thesis › Doctor of Philosophy

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title = "CXCL-8-dependent and -independent neutrophil activation in COPD: experiences from a pilot study of the CXCR2 antagonist danirixin",

abstract = "The implications of these findings are significant for development of CXCR2 antagonists and other mechanisms targeting neutrophil activation or NETosis, suggesting that IL-8-dependent mechanisms will only work in a subset of COPD patients https://bit.ly/32SeisO.",

author = "Keir, \{Holly R.\} and Hollian Richardson and Christina Fillmore and Amelia Shoemark and Lazaar, \{Aili L.\} and Miller, \{Bruce E.\} and Ruth Tal-Singer and Chalmers, \{James D.\} and Divya Mohan",

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AU - Keir, Holly R.

AU - Richardson, Hollian

AU - Fillmore, Christina

AU - Shoemark, Amelia

AU - Lazaar, Aili L.

AU - Miller, Bruce E.

AU - Tal-Singer, Ruth

AU - Chalmers, James D.

AU - Mohan, Divya

N1 - Funding GSK 207551

PY - 2020/11/10

Y1 - 2020/11/10

N2 - The implications of these findings are significant for development of CXCR2 antagonists and other mechanisms targeting neutrophil activation or NETosis, suggesting that IL-8-dependent mechanisms will only work in a subset of COPD patients https://bit.ly/32SeisO.

AB - The implications of these findings are significant for development of CXCR2 antagonists and other mechanisms targeting neutrophil activation or NETosis, suggesting that IL-8-dependent mechanisms will only work in a subset of COPD patients https://bit.ly/32SeisO.

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DO - 10.1183/23120541.00583-2020

M3 - Article

C2 - 33263062

SN - 2312-0541

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JO - ERJ Open Research

JF - ERJ Open Research

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ER -

CXCL-8-dependent and -independent neutrophil activation in COPD: experiences from a pilot study of the CXCR2 antagonist danirixin

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Student theses

Neutrophil extracellular traps in chronic lung disease

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