TY - JOUR
T1 - Cyanotoxins, biosynthetic gene clusters, and factors modulating cyanotoxin biosynthesis
AU - Bashir, Fahim
AU - Bashir, Arif
AU - Bouaïcha, Noureddine
AU - Chen, Liang
AU - Codd, Geoffrey A.
AU - Neilan, Brett
AU - Xu, Wen-Li
AU - Ziko, Laila
AU - Rajput, Vishnu D.
AU - Minkina, Tatiana
AU - Arruda, Renan Silva
AU - Ganai, Bashir Ahmad
N1 - Funding Information:
Arif Bashir would like to acknowledge the Department of Science & Technology (DST), Science and Engineering Research Board (SERB), New Delhi, India for providing grant-in-aid under the National Postdoctoral fellowship scheme under the file number PDF/2017/001894. Liang Chen was supported by the Special Project for Social Development of Yunnan Province (grant number 202103AC100001), the Natural Science Basic Research Program of Shaanxi Province (grant number 2020JQ-615) and the National Natural Science Foundation of China (grant number 31901186).
Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Nature B.V.
PY - 2023/7/3
Y1 - 2023/7/3
N2 - Cyanobacterial harmful algal blooms (CHABs) are a global environmental concern that encompasses public health issues, water availability, and water quality owing to the production of various secondary metabolites (SMs), including cyanotoxins in freshwater, brackish water, and marine ecosystems. The frequency, extent, magnitude, and duration of CHABs are increasing globally. Cyanobacterial species traits and changing environmental conditions, including anthropogenic pressure, eutrophication, and global climate change, together allow cyanobacteria to thrive. The cyanotoxins include a diverse range of low molecular weight compounds with varying biochemical properties and modes of action. With the application of modern molecular biology techniques, many important aspects of cyanobacteria are being elucidated, including aspects of their diversity, gene-environment interactions, and genes that express cyanotoxins. The toxicological, environmental, and economic impacts of CHABs strongly advocate the need for continuing, extensive efforts to monitor cyanobacterial growth and to understand the mechanisms regulating species composition and cyanotoxin biosynthesis. In this review, we critically examined the genomic organization of some cyanobacterial species that lead to the production of cyanotoxins and their characteristic properties discovered to date.
AB - Cyanobacterial harmful algal blooms (CHABs) are a global environmental concern that encompasses public health issues, water availability, and water quality owing to the production of various secondary metabolites (SMs), including cyanotoxins in freshwater, brackish water, and marine ecosystems. The frequency, extent, magnitude, and duration of CHABs are increasing globally. Cyanobacterial species traits and changing environmental conditions, including anthropogenic pressure, eutrophication, and global climate change, together allow cyanobacteria to thrive. The cyanotoxins include a diverse range of low molecular weight compounds with varying biochemical properties and modes of action. With the application of modern molecular biology techniques, many important aspects of cyanobacteria are being elucidated, including aspects of their diversity, gene-environment interactions, and genes that express cyanotoxins. The toxicological, environmental, and economic impacts of CHABs strongly advocate the need for continuing, extensive efforts to monitor cyanobacterial growth and to understand the mechanisms regulating species composition and cyanotoxin biosynthesis. In this review, we critically examined the genomic organization of some cyanobacterial species that lead to the production of cyanotoxins and their characteristic properties discovered to date.
KW - Cyanobacteria Toxins
KW - Marine Toxins/metabolism
KW - Ecosystem
KW - Fresh Water/microbiology
KW - Cyanobacteria/metabolism
KW - Multigene Family
KW - Microcystins/genetics
KW - Anatoxins
KW - Cyanotoxins
KW - Biosynthesis
KW - Environmental factors
KW - Gene expression
KW - Saxitoxins
KW - Cylindrospermopsins
KW - Microcystins
U2 - 10.1007/s11274-023-03652-x
DO - 10.1007/s11274-023-03652-x
M3 - Review article
C2 - 37394567
SN - 0959-3993
VL - 39
JO - World Journal of Microbiology and Biotechnology
JF - World Journal of Microbiology and Biotechnology
IS - 9
M1 - 241
ER -