Cyclic Nrarp mRNA expression is regulated by the somitic oscillator but Nrarp protein levels do not oscillate

David Wright, Zoltan Ferjentsik, Shang-Wei Chong, Xuehui Qiu, Yun-Jin Jiang, Pascale Malapert, Olivier Pourquie, Nick Van Hateren, Stuart A. Wilson, Claudio Franco, Holger Gerhardt, J. Kim Dale, Miguel Maroto

    Research output: Contribution to journalArticlepeer-review

    16 Citations (Scopus)


    Somites are formed progressively from the presomitic mesoderm (PSM) in a highly regulated process according to a strict periodicity driven by an oscillatory mechanism. The Notch and Wnt pathways are key components in the regulation of this somitic oscillator and data from Xenopus and zebrafish embryos indicate that the Notch-downstream target Nrarp participates in the regulation of both activities. We have analyzed Nrarp/nrarp-a expression in the PSM of chick, mouse and zebrafish embryos, and we show that it cycles in synchrony with other Notch regulated cyclic genes. In the mouse its transcription is both Wnt- and Notch-dependent, whereas in the chick and fish embryo it is simply Notch-dependent. Despite oscillating mRNA levels, Nrarp protein does not oscillate in the PSM. Finally, neither gain nor loss of Nrarp function interferes with the normal expression of Notch-related cyclic genes. Developmental Dynamics 238:3043-3055, 2009. (C) 2009 Wiley-Liss, Inc.

    Original languageEnglish
    Pages (from-to)3043-3055
    Number of pages13
    JournalDevelopmental Dynamics
    Issue number12
    Publication statusPublished - Dec 2009


    • Nrarp
    • Notch pathway
    • Embryo
    • Somitic oscillator
    • PSM
    • Cyclic gene
    • Notch signaling pathway
    • Presomitic mesoderm
    • Segmentation clock
    • Primitive streak
    • Gene expression
    • Chick embryo
    • Zebrafish somitogenesis
    • Differentiation
    • Cells
    • Fate


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