Keyphrases
Major Determinants
100%
Activity in Vivo
100%
Human Cytochrome P450
100%
Cytochrome P-450 CYP2D6
100%
Cytochrome P450 3A4 (CYP3A4)
100%
Cytochrome b5
100%
Cytochrome P450 2D6 (CYP2D6)
50%
Hydroxylation
37%
Debrisoquine
37%
Triazolam
37%
Metabolism
25%
Therapeutic Agents
25%
Bufuralol
25%
Pharmacokinetics
12%
Potential Impact
12%
Recombinant
12%
Concentration-dependent
12%
In Vitro Study
12%
Microsomes
12%
Cytochrome P450 Reductase
12%
P450s
12%
P450
12%
Cytochrome P450 Monooxygenase
12%
P450 Activity
12%
Chemopreventive
12%
Cytochrome P450 (CYP450)
12%
Drug Disposition
12%
Metoprolol
12%
Humanized
12%
Monooxygenase System
12%
Drug Pharmacokinetics
12%
Hepatic Microsomes
12%
Area under the Concentration-time Curve
12%
Electron Transfer
12%
Chemical Carcinogens
12%
Biological Toxins
12%
E. Coli Membrane
12%
CYP2D6 Activity
12%
Peak Plasma Concentration
12%
Biochemistry, Genetics and Molecular Biology
CYP2D6
100%
CYP3A4
100%
Cytochrome B5
100%
Cytochrome P450
50%
Hydroxylation
37%
Triazolam
37%
Pharmacokinetics
25%
Metabolic Pathway
25%
Enzyme
12%
Escherichia coli
12%
Cytochrome P450 Reductase
12%
Unspecific Monooxygenase
12%
In Vitro Study
12%
Drug Disposition
12%
Maximum Plasma Concentration
12%
Metoprolol
12%
Electron Transfer
12%
Pharmacology, Toxicology and Pharmaceutical Science
CYP2D6
100%
CYP3A4
100%
Cytochrome B5
100%
Cytochrome P450
50%
Debrisoquine
37%
Triazolam
37%
Bufuralol
25%
Pharmacokinetics
25%
Carcinogen
12%
Escherichia coli
12%
Side Effect
12%
Chemopreventive Agents
12%
Cytochrome P450 Reductase
12%
Unspecific Monooxygenase
12%
Metoprolol
12%