Cytochrome P-450: Localization in rabbit lung

Cosette J. Serabjit-Singh, C. Roland Wolf, Richard M. Philpot, Charles G. Plopper

Research output: Contribution to journalArticle

143 Citations (Scopus)

Abstract

Cytochrome P-450-dependent monooxygenase systems, which metabolize endogenous as well as foreign compounds, are found in hepatic and several extrahepatic tissues of mammals, including humans. A form of cytochrome P-450 is localized in the nonciliated bronchiolar epithelial cells (Clara cells) of the small airways of rabbit lung. The apparent high concentration of the cytochrome in this pulmonary cell type compared to liver may be an important determinant in the susceptibility of the lung to a number of toxic chemicals that undergo metabolic activation.

Original languageEnglish
Pages (from-to)1469-1470
Number of pages2
JournalScience
Volume207
Issue number4438
DOIs
Publication statusPublished - 28 Mar 1980

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    Serabjit-Singh, C. J., Wolf, C. R., Philpot, R. M., & Plopper, C. G. (1980). Cytochrome P-450: Localization in rabbit lung. Science, 207(4438), 1469-1470. https://doi.org/10.1126/science.6767272