Cytochrome P-450: Localization in rabbit lung

Cosette J. Serabjit-Singh; C. Roland Wolf; Richard M. Philpot; Charles G. Plopper

doi:10.1126/science.6767272

Cytochrome P-450: Localization in rabbit lung

Cosette J. Serabjit-Singh, C. Roland Wolf, Richard M. Philpot, Charles G. Plopper

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Abstract

Cytochrome P-450-dependent monooxygenase systems, which metabolize endogenous as well as foreign compounds, are found in hepatic and several extrahepatic tissues of mammals, including humans. A form of cytochrome P-450 is localized in the nonciliated bronchiolar epithelial cells (Clara cells) of the small airways of rabbit lung. The apparent high concentration of the cytochrome in this pulmonary cell type compared to liver may be an important determinant in the susceptibility of the lung to a number of toxic chemicals that undergo metabolic activation.

Original language	English
Pages (from-to)	1469-1470
Number of pages	2
Journal	Science
Volume	207
Issue number	4438
DOIs	https://doi.org/10.1126/science.6767272
Publication status	Published - 28 Mar 1980

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abstract = "Cytochrome P-450-dependent monooxygenase systems, which metabolize endogenous as well as foreign compounds, are found in hepatic and several extrahepatic tissues of mammals, including humans. A form of cytochrome P-450 is localized in the nonciliated bronchiolar epithelial cells (Clara cells) of the small airways of rabbit lung. The apparent high concentration of the cytochrome in this pulmonary cell type compared to liver may be an important determinant in the susceptibility of the lung to a number of toxic chemicals that undergo metabolic activation.",

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AU - Serabjit-Singh, Cosette J.

AU - Wolf, C. Roland

AU - Philpot, Richard M.

AU - Plopper, Charles G.

PY - 1980/3/28

Y1 - 1980/3/28

N2 - Cytochrome P-450-dependent monooxygenase systems, which metabolize endogenous as well as foreign compounds, are found in hepatic and several extrahepatic tissues of mammals, including humans. A form of cytochrome P-450 is localized in the nonciliated bronchiolar epithelial cells (Clara cells) of the small airways of rabbit lung. The apparent high concentration of the cytochrome in this pulmonary cell type compared to liver may be an important determinant in the susceptibility of the lung to a number of toxic chemicals that undergo metabolic activation.

AB - Cytochrome P-450-dependent monooxygenase systems, which metabolize endogenous as well as foreign compounds, are found in hepatic and several extrahepatic tissues of mammals, including humans. A form of cytochrome P-450 is localized in the nonciliated bronchiolar epithelial cells (Clara cells) of the small airways of rabbit lung. The apparent high concentration of the cytochrome in this pulmonary cell type compared to liver may be an important determinant in the susceptibility of the lung to a number of toxic chemicals that undergo metabolic activation.

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SP - 1469

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JF - Science

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ER -

Cytochrome P-450: Localization in rabbit lung

Abstract

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