Cytochrome P-450s: polymorphic multigene families involved in carcinogen activation

C. R. Wolf

doi:10.1016/0168-9525(86)90232-5

Cytochrome P-450s: polymorphic multigene families involved in carcinogen activation

C. R. Wolf

Research output: Contribution to journal › Article › peer-review

102 Citations (Scopus)

Abstract

The polymorphic expression of cytochrome P-450 genes appears to be an important factor in adverse reactions to drugs, environmental toxins and chemical carcinogens. An understanding of the molecular basis of these polymorphisms may enable prediction and prevention of some of these effects. The high degree of polymorphism of this multigene family and scattered distribution of the subfamilies in the human genome may well provide useful markers for gene mapping and the study of genetic linkage in human disease.

Original language	English
Pages (from-to)	209-214
Number of pages	6
Journal	Trends in Genetics
Volume	2
Issue number	C
DOIs	https://doi.org/10.1016/0168-9525(86)90232-5
Publication status	Published - 1986

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

General Medicine
Genetics

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10.1016/0168-9525(86)90232-5

Cite this

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title = "Cytochrome P-450s: polymorphic multigene families involved in carcinogen activation",

abstract = "The polymorphic expression of cytochrome P-450 genes appears to be an important factor in adverse reactions to drugs, environmental toxins and chemical carcinogens. An understanding of the molecular basis of these polymorphisms may enable prediction and prevention of some of these effects. The high degree of polymorphism of this multigene family and scattered distribution of the subfamilies in the human genome may well provide useful markers for gene mapping and the study of genetic linkage in human disease.",

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AU - Wolf, C. R.

PY - 1986

Y1 - 1986

N2 - The polymorphic expression of cytochrome P-450 genes appears to be an important factor in adverse reactions to drugs, environmental toxins and chemical carcinogens. An understanding of the molecular basis of these polymorphisms may enable prediction and prevention of some of these effects. The high degree of polymorphism of this multigene family and scattered distribution of the subfamilies in the human genome may well provide useful markers for gene mapping and the study of genetic linkage in human disease.

AB - The polymorphic expression of cytochrome P-450 genes appears to be an important factor in adverse reactions to drugs, environmental toxins and chemical carcinogens. An understanding of the molecular basis of these polymorphisms may enable prediction and prevention of some of these effects. The high degree of polymorphism of this multigene family and scattered distribution of the subfamilies in the human genome may well provide useful markers for gene mapping and the study of genetic linkage in human disease.

UR - https://www.scopus.com/pages/publications/0003090917

U2 - 10.1016/0168-9525(86)90232-5

DO - 10.1016/0168-9525(86)90232-5

M3 - Article

AN - SCOPUS:0003090917

SN - 0168-9525

VL - 2

SP - 209

EP - 214

JO - Trends in Genetics

JF - Trends in Genetics

IS - C

ER -

Cytochrome P-450s: polymorphic multigene families involved in carcinogen activation

Abstract

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