Cytocompatibility, Interactions, and Uptake of Polyethyleneimine-Coated Boron Nitride Nanotubes by Living Cells: Confirmation of Their Potential for Biomedical Applications

Gianni Ciofani, Vittoria Raffa, Arianna Menciassi, Alfred Cuschieri

    Research output: Contribution to journalArticle

    151 Citations (Scopus)

    Abstract

    Boron nitride nanotubes (BNNTs) have unique physical properties, which can be exploited in the biomedical field. Hence, the surprising lack of reported studies on their biocompatibility and interactions with living cells, addressed by the present paper which deals the results of such an investigation based on 72 h culture of human neuroblastoma cell line (SH-SY5Y) in the presence of an aqueous suspension of polyethyleneimine (PEI)-coated BNNTs. BNNTs conjugated with fluorescent markers (quantum dots) are employed to enable tracking of their uptake by living cells. The results demonstrate good cyto-compatibility together with unequivocal BNNT cellular uptake by an energy-dependent endocytic process.

    Original languageEnglish
    Pages (from-to)850-858
    Number of pages9
    JournalBiotechnology and Bioengineering
    Volume101
    Issue number4
    DOIs
    Publication statusPublished - 1 Nov 2008

    Keywords

    • boron nitride nanotubes
    • biocompatibility
    • quantum dots
    • cell uptake
    • endocytosis
    • CARBON NANOTUBES
    • ELASTIC-MODULUS
    • GENE DELIVERY
    • BN NANOTUBES
    • IN-VITRO
    • IMMOBILIZATION
    • TRANSPORTERS
    • ENDOCYTOSIS
    • MECHANISM
    • PROTEINS

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