Cytoskeleton out of the cupboard: Colon cancer and cytoskeletal changes induced by loss of APC

TY - JOUR

T1 - Cytoskeleton out of the cupboard

T2 - Colon cancer and cytoskeletal changes induced by loss of APC

AU - Näthke, Inke

PY - 2006/12/1

Y1 - 2006/12/1

N2 - Mutation of APC (adenomatous polyposis coli) is a common factor in most colorectal cancers. APC has many functions, the most prominent is its capacity to regulate β-catenin-mediated gene transcription in response to Wnt signalling. Loss of APC leads to deregulated β-catenin and this is intimately linked with tumour formation. However, recent evidence indicates that the interaction of APC with the cytoskeleton might also contribute to tumour initiation and progression. How does APC interact with the cytoskeleton and how could this play a part in colorectal tumorigenesis?

AB - Mutation of APC (adenomatous polyposis coli) is a common factor in most colorectal cancers. APC has many functions, the most prominent is its capacity to regulate β-catenin-mediated gene transcription in response to Wnt signalling. Loss of APC leads to deregulated β-catenin and this is intimately linked with tumour formation. However, recent evidence indicates that the interaction of APC with the cytoskeleton might also contribute to tumour initiation and progression. How does APC interact with the cytoskeleton and how could this play a part in colorectal tumorigenesis?

UR - https://www.scopus.com/pages/publications/33845234807

U2 - 10.1038/nrc2010

DO - 10.1038/nrc2010

M3 - Review article

C2 - 17093505

AN - SCOPUS:33845234807

SN - 1474-175X

VL - 6

SP - 967

EP - 974

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

IS - 12

ER -