Data from human salivary proteome: A resource of potential biomarkers for oral cancer

Priya Sivadasan, Manoj Kumar Gupta, Gajanan J. Sathe, Lavanya Balakrishnan, Priyanka Palit, Harsha Gowda, Amritha Suresh, Moni Abraham Kuriakose, Ravi Sirdeshmukh

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Salivary proteins are an important source for developing marker-based assays for oral cancers. To get an insight into the proteins present in human saliva, we applied multiple strategies involving affinity-based depletion of abundant proteins, fractionation of the resulting proteins or their tryptic peptides followed by LC-MS/MS analysis, using high resolution mass spectrometry. By integrating the protein identifications observed by us with those from similar workflows employed in earlier investigations, we compiled an updated salivary proteome. We have mapped the salivary proteome to the published data on differentially expressed proteins from oral cancer tissues and also for their secretory features using prediction tools, SignalP 4.1, TMHMM 2c and Exocarta. Proteotypic peptides for the subset of proteins implicated in oral cancer and mapped to any two of the prediction tools for secretory potential have been listed. The data here are related to the research article "Human saliva proteome - a resource of potential biomarkers for oral cancer" in the Journal of Proteomics [1].

Original languageEnglish
Pages (from-to)374-378
Number of pages5
JournalData in Brief
Volume4
DOIs
Publication statusPublished - Sep 2015

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