TY - JOUR
T1 - Data from human salivary proteome
T2 - A resource of potential biomarkers for oral cancer
AU - Sivadasan, Priya
AU - Kumar Gupta, Manoj
AU - Sathe, Gajanan J.
AU - Balakrishnan, Lavanya
AU - Palit, Priyanka
AU - Gowda, Harsha
AU - Suresh, Amritha
AU - Abraham Kuriakose, Moni
AU - Sirdeshmukh, Ravi
N1 - Funding Information:
We acknowledge the Department of Biotechnology (DBT) , Government of India ( BT/PR13505/Med/30/276/2010 and BT/01/CEIB/11/IV/05 Dated 22/08/13 ) for financial support.
Publisher Copyright:
© 2015 The Authors.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2015/9
Y1 - 2015/9
N2 - Salivary proteins are an important source for developing marker-based assays for oral cancers. To get an insight into the proteins present in human saliva, we applied multiple strategies involving affinity-based depletion of abundant proteins, fractionation of the resulting proteins or their tryptic peptides followed by LC-MS/MS analysis, using high resolution mass spectrometry. By integrating the protein identifications observed by us with those from similar workflows employed in earlier investigations, we compiled an updated salivary proteome. We have mapped the salivary proteome to the published data on differentially expressed proteins from oral cancer tissues and also for their secretory features using prediction tools, SignalP 4.1, TMHMM 2c and Exocarta. Proteotypic peptides for the subset of proteins implicated in oral cancer and mapped to any two of the prediction tools for secretory potential have been listed. The data here are related to the research article "Human saliva proteome - a resource of potential biomarkers for oral cancer" in the Journal of Proteomics [1].
AB - Salivary proteins are an important source for developing marker-based assays for oral cancers. To get an insight into the proteins present in human saliva, we applied multiple strategies involving affinity-based depletion of abundant proteins, fractionation of the resulting proteins or their tryptic peptides followed by LC-MS/MS analysis, using high resolution mass spectrometry. By integrating the protein identifications observed by us with those from similar workflows employed in earlier investigations, we compiled an updated salivary proteome. We have mapped the salivary proteome to the published data on differentially expressed proteins from oral cancer tissues and also for their secretory features using prediction tools, SignalP 4.1, TMHMM 2c and Exocarta. Proteotypic peptides for the subset of proteins implicated in oral cancer and mapped to any two of the prediction tools for secretory potential have been listed. The data here are related to the research article "Human saliva proteome - a resource of potential biomarkers for oral cancer" in the Journal of Proteomics [1].
UR - https://www.scopus.com/pages/publications/84938073238
U2 - 10.1016/j.dib.2015.06.014
DO - 10.1016/j.dib.2015.06.014
M3 - Article
AN - SCOPUS:84938073238
SN - 2352-3409
VL - 4
SP - 374
EP - 378
JO - Data in Brief
JF - Data in Brief
ER -
