Dataset for the reporting of carcinoma of renal tubular origin: recommendations from the International Collaboration on Cancer Reporting (ICCR)

Brett Delahunt (Lead / Corresponding author), John R. Srigley, Meagan J. Judge, Mahul B. Amin, Athanase Billis, Philippe Camparo, Andrew J. Evans, Stewart Fleming, David F. Griffiths, Antonio Lopez-Beltran, Guido Martignoni, Holger Moch, John N. Nacey, Ming Zhou

    Research output: Contribution to journalReview articlepeer-review

    8 Citations (Scopus)
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    Abstract

    Aims: The International Collaboration on Cancer Reporting (ICCR) has provided detailed data sets based upon the published reporting protocols of the Royal College of Pathologists, the Royal College of Pathologists of Australasia and the College of American Pathologists.

    Methods and results: The data set for carcinomas of renal tubular origin treated by nephrectomy was developed to provide a minimum structured reporting template suitable for international use, and incorporated recommendations from the 2012 Vancouver Consensus Conference of the International Society of Urological Pathology (ISUP) and the fourth edition of the World Health Organisation Bluebook on tumours of the urinary and male genital systems published in 2016. Reporting elements were divided into those, which are required and recommended components of the report. Required elements are: specimen laterality, operative procedure, attached structures, tumour focality, tumour dimension, tumour type, WHO/ISUP grade, sarcomatoid/rhabdoid morphology, tumour necrosis, extent of invasion, lymph node status, surgical margin status, AJCC TNM staging and co-existing pathology. Recommended reporting elements are: pre-operative treatment, details of tissue removed for experimental purposes prior to submission, site of tumour(s) block identification key, extent of sarcomatoid and/or rhabdoid component, extent of necrosis, presence of tumour in renal vein wall, lymphovascular invasion and lymph node status (size of largest focus and extranodal extension).

    Conclusions: It is anticipated that the implementation of this data set in routine clinical practice will inform patient treatment as well as provide standardised information relating to outcome prediction. The harmonisation of data reporting should also facilitate international research collaborations.

    Original languageEnglish
    Pages (from-to)377-390
    Number of pages14
    JournalHistopathology
    Volume74
    Issue number3
    Early online date16 Oct 2018
    DOIs
    Publication statusPublished - Feb 2019

    Keywords

    • data sets
    • grading
    • nephrectomy
    • renal cell carcinoma
    • staging
    • tumour

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