Daylight photodynamic therapy in Scotland

Helen Cordey, Ronan Valentine, Andrea Lesar, Harry Moseley, Ewan Eadie, Sally Ibbotson (Lead / Corresponding author)

Research output: Contribution to journalArticle

5 Citations (Scopus)
516 Downloads (Pure)

Abstract

Chronic sun-induced dysplastic skin changes (actinic keratoses) are extremely common in fair-skinned people in Scotland. These changes are a major cause of morbidity and may develop into skin cancer. Actinic keratoses are often extensive and pose a therapeutic challenge as field-directed treatment is required for chronic disease management. One such treatment approach is hospital-based photodynamic therapy (PDT), which is a well-established treatment in Scotland for actinic keratoses, using a photosensitiser pro-drug and red LED light irradiation. However, PDT using daylight as the activating light source is increasingly and effectively used in continental Europe, but had not been explored in Scotland until we initiated this in 2013. We report our experience of daylight PDT in 64 patient treatment courses and demonstrate that this can be an effective, well-tolerated treatment, which is liked by patients. Most patients (73%) achieved clearance or at least a good response to treatment and had high levels of satisfaction with daylight PDT. Daylight exposure measurements indicated that treatment is feasible in Scotland between April to September. Daylight PDT is an important advance in treatment options for Scottish patients with extensive pre-cancerous field changes and provides opportunities for home-based treatment and increased efficiency of PDT services.
Original languageEnglish
Pages (from-to)48-53
Number of pages6
JournalScottish Medical Journal
Volume62
Issue number2
Early online date16 May 2017
DOIs
Publication statusPublished - May 2017

    Fingerprint

Keywords

  • Actinic keratoses
  • Daylight
  • photodynamic therapy

Cite this