DEAD box RNA helicase functions in cancer

Frances V. Fuller-Pace

    Research output: Contribution to journalArticlepeer-review

    147 Citations (Scopus)


    Members of the DEAD box family of RNA helicases are known to be involved in most cellular processes that require manipulation of RNA structure and, in many cases, exhibit other functions in addition to their established ATP-dependent RNA helicase activities. They thus play critical roles in cellular metabolism and in many cases have been implicated in cellular proliferation and/or neoplastic transformation. These proteins generally act as components of multi-protein complexes; therefore their precise role is likely to be influenced by their interacting partners and to be highly context-dependent. This may also provide an explanation for the sometimes conflicting reports suggesting that DEAD box proteins have both pro- and anti-proliferative roles in cancer.
    Original languageEnglish
    Pages (from-to)121-132
    Number of pages12
    JournalRNA Biology
    Issue number1
    Publication statusPublished - 2013


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