Attention-deficit/hyperactivity disorder (ADHD) is one of the most common diagnoses in child and adolescent mental health services, in the United States as well as in many other countries. Medication, including stimulant and nonstimulant options, is an important element of the multimodal approach to ADHD management. Stimulants are recommended as the first-line pharmacological treatment. 1 A recent study including data from more than 150 million individuals in 13 countries showed an increase in the prevalence of ADHD medications use over the past 15 years in all countries, albeit with large variations across countries. 2 One of the aspects that remains controversial in relation to stimulants pertains to their long-term effectiveness.