Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease

C. A.D. Smith; C.R. Wolf; A. C. Gough; N. K. Spurr; P. N. Leigh; B. A. Summers; A. E. Harding; D. M. Maranganore; S. G. Sturman; A. C. Williams; A. H.V. Schapira

doi:10.1016/0140-6736(92)91196-F

Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease

C. A.D. Smith, C.R. Wolf, A. C. Gough, N. K. Spurr, P. N. Leigh, B. A. Summers, A. E. Harding, D. M. Maranganore, S. G. Sturman, A. C. Williams, A. H.V. Schapira

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Abstract

The pathogenesis of Parkinson's disease may be influenced by genetic and environmental factors. Cytochrome P450 mono-oxygenases help to protect against toxic environmental compounds and individual variations in cytochrome P450 expression might, therefore, influence susceptibility to environmentally linked diseases. The frequency of mutant CYP2D6 alleles was studied in 229 patients with Parkinson's disease and 720 controls. Individuals with a metabolic defect in the cytochrome P450 CYP2D6-debrisoquine hydroxylase gene with the poor metaboliser phenotype had a 2·54-fold (95% Cl 1·51-4·28) increased risk of Parkinson's disease. Determination of CYP2D6 phenotype and genotype may help to identify those at greatest risk of Parkinson's disease and may also help to identify the environmental or metabolic agents involved in the pathogenesis of this disease.

Original language	English
Pages (from-to)	1375-1377
Number of pages	3
Journal	The Lancet
Volume	339
Issue number	8806
DOIs	https://doi.org/10.1016/0140-6736(92)91196-F
Publication status	Published - 6 Jun 1992

ASJC Scopus subject areas

General Medicine

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title = "Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease",

abstract = "The pathogenesis of Parkinson's disease may be influenced by genetic and environmental factors. Cytochrome P450 mono-oxygenases help to protect against toxic environmental compounds and individual variations in cytochrome P450 expression might, therefore, influence susceptibility to environmentally linked diseases. The frequency of mutant CYP2D6 alleles was studied in 229 patients with Parkinson's disease and 720 controls. Individuals with a metabolic defect in the cytochrome P450 CYP2D6-debrisoquine hydroxylase gene with the poor metaboliser phenotype had a 2·54-fold (95% Cl 1·51-4·28) increased risk of Parkinson's disease. Determination of CYP2D6 phenotype and genotype may help to identify those at greatest risk of Parkinson's disease and may also help to identify the environmental or metabolic agents involved in the pathogenesis of this disease.",

author = "Smith, {C. A.D.} and C.R. Wolf and Gough, {A. C.} and Spurr, {N. K.} and Leigh, {P. N.} and Summers, {B. A.} and Harding, {A. E.} and Maranganore, {D. M.} and Sturman, {S. G.} and Williams, {A. C.} and Schapira, {A. H.V.}",

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doi = "10.1016/0140-6736(92)91196-F",

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T1 - Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease

AU - Smith, C. A.D.

AU - Wolf, C.R.

AU - Gough, A. C.

AU - Spurr, N. K.

AU - Leigh, P. N.

AU - Summers, B. A.

AU - Harding, A. E.

AU - Maranganore, D. M.

AU - Sturman, S. G.

AU - Williams, A. C.

AU - Schapira, A. H.V.

PY - 1992/6/6

Y1 - 1992/6/6

N2 - The pathogenesis of Parkinson's disease may be influenced by genetic and environmental factors. Cytochrome P450 mono-oxygenases help to protect against toxic environmental compounds and individual variations in cytochrome P450 expression might, therefore, influence susceptibility to environmentally linked diseases. The frequency of mutant CYP2D6 alleles was studied in 229 patients with Parkinson's disease and 720 controls. Individuals with a metabolic defect in the cytochrome P450 CYP2D6-debrisoquine hydroxylase gene with the poor metaboliser phenotype had a 2·54-fold (95% Cl 1·51-4·28) increased risk of Parkinson's disease. Determination of CYP2D6 phenotype and genotype may help to identify those at greatest risk of Parkinson's disease and may also help to identify the environmental or metabolic agents involved in the pathogenesis of this disease.

AB - The pathogenesis of Parkinson's disease may be influenced by genetic and environmental factors. Cytochrome P450 mono-oxygenases help to protect against toxic environmental compounds and individual variations in cytochrome P450 expression might, therefore, influence susceptibility to environmentally linked diseases. The frequency of mutant CYP2D6 alleles was studied in 229 patients with Parkinson's disease and 720 controls. Individuals with a metabolic defect in the cytochrome P450 CYP2D6-debrisoquine hydroxylase gene with the poor metaboliser phenotype had a 2·54-fold (95% Cl 1·51-4·28) increased risk of Parkinson's disease. Determination of CYP2D6 phenotype and genotype may help to identify those at greatest risk of Parkinson's disease and may also help to identify the environmental or metabolic agents involved in the pathogenesis of this disease.

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U2 - 10.1016/0140-6736(92)91196-F

DO - 10.1016/0140-6736(92)91196-F

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VL - 339

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JO - The Lancet

JF - The Lancet

IS - 8806

ER -

Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease

Abstract

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