Deciphering the function of leucine-rich repeat kinase 2 and targeting its dysfunction in disease

Patrick A. Lewis; Dario R. Alessi

doi:10.1042/BST20120178

Deciphering the function of leucine-rich repeat kinase 2 and targeting its dysfunction in disease

Patrick A. Lewis, Dario R. Alessi

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

LRRK2 (leucine-rich repeat kinase 2) is a gene of unknown function that has been linked to a number a human diseases, including PD (Parkinson's disease), IBD (inflammatory bowel disease), leprosy and cancer. The papers from the LRRK2: Function and Dysfunction meeting in this issue of Biochemical Society Transactions explore our growing knowledge of LRRK2's normal function, the role that it plays in disease and emerging strategies to exploit LRRK2 as a therapeutic target.

Original language	English
Pages (from-to)	1039-1041
Number of pages	3
Journal	Biochemical Society Transactions
Volume	40
Issue number	5
DOIs	https://doi.org/10.1042/BST20120178
Publication status	Published - 2012

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10.1042/BST20120178

A Systematic Investigation into the Pathogenesis and Course of Parkinson's Syndrome (Wellcome Trust and MRC Neurodegenerative Diseases Initiative) (Joint with University College London)
Alessi, D. (Investigator)
Medical Research Council
1/09/10 → 31/08/15
Project: Research

Cite this

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abstract = "LRRK2 (leucine-rich repeat kinase 2) is a gene of unknown function that has been linked to a number a human diseases, including PD (Parkinson's disease), IBD (inflammatory bowel disease), leprosy and cancer. The papers from the LRRK2: Function and Dysfunction meeting in this issue of Biochemical Society Transactions explore our growing knowledge of LRRK2's normal function, the role that it plays in disease and emerging strategies to exploit LRRK2 as a therapeutic target.",

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Deciphering the function of leucine-rich repeat kinase 2 and targeting its dysfunction in disease

Abstract

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Projects

A Systematic Investigation into the Pathogenesis and Course of Parkinson's Syndrome (Wellcome Trust and MRC Neurodegenerative Diseases Initiative) (Joint with University College London)

Cite this