Decreased intestinal CYP3A in celiac disease: reversal after successful gluten-free diet: a potential source of interindividual variability in first-pass drug metabolism

Chim C. Lang, R. Michael Brown, Mark T. Kinirons, Mary-Ann Deathridge, F. Peter Guengerich, Dermot Kelleher, D. Sean O'Briain, Fayez K. Ghishan, Alastair J. J. Wood

    Research output: Contribution to journalArticlepeer-review

    45 Citations (Scopus)

    Abstract

    Cytochrome P450 (CYP) 3A is constitutively expressed in human intestinal villi and may account for significant "first-pass" prehepatic metabolism of a number of drugs in the intestine. Celiac disease results in small intestinal atrophy. We hypothesized that this would result in a loss of CYP3A.
    Original languageEnglish
    Pages (from-to)41-46
    Number of pages6
    JournalClinical Pharmacology & Therapeutics
    Volume59
    Issue number1
    DOIs
    Publication statusPublished - 1996

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