Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study

Edward Burn; Seng Chan You; Anthony G. Sena; Kristin Kostka; Hamed Abedtash; Maria Tereza F. Abrahão; Amanda Alberga; Heba Alghoul; Osaid Alser; Thamir M. Alshammari; Maria Aragon; Carlos Areia; Juan M. Banda; Jaehyeong Cho; Aedin C. Culhane; Alexander Davydov; Frank J. DeFalco; Talita Duarte-Salles; Scott DuVall; Thomas Falconer; Sergio Fernandez-Bertolin; Weihua Gao; Asieh Golozar; Jill Hardin; George Hripcsak; Vojtech Huser; Hokyun Jeon; Yonghua Jing; Chi Young Jung; Benjamin Skov Kaas-Hansen; Denys Kaduk; Seamus Kent; Yeesuk Kim; Spyros Kolovos; Jennifer C. E. Lane; Hyejin Lee; Kristine E. Lynch; Rupa Makadia; Michael E. Matheny; Paras P. Mehta; Daniel R. Morales; Karthik Natarajan; Fredrik Nyberg; Anna Ostropolets; Rae Woong Park; Jimyung Park; Jose D. Posada; Albert Prats-Uribe; Gowtham Rao; Christian Reich; Yeunsook Rho; Peter Rijnbeek; Lisa M. Schilling; Martijn Schuemie; Nigam H. Shah; Azza Shoaibi; Seokyoung Song; Matthew Spotnitz; Marc A. Suchard; Joel N. Swerdel; David Vizcaya; Salvatore Volpe; Haini Wen; Andrew E. Williams; Belay B Yimer; Lin Zhang; Oleg Zhuk; Daniel Prieto-Alhambra; Patrick Ryan

doi:10.1038/s41467-020-18849-z

Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study

Edward Burn, Seng Chan You, Anthony G. Sena, Kristin Kostka, Hamed Abedtash, Maria Tereza F. Abrahão, Amanda Alberga, Heba Alghoul, Osaid Alser, Thamir M. Alshammari, Maria Aragon, Carlos Areia, Juan M. Banda, Jaehyeong Cho, Aedin C. Culhane, Alexander Davydov, Frank J. DeFalco, Talita Duarte-Salles, Scott DuVall, Thomas FalconerSergio Fernandez-Bertolin, Weihua Gao, Asieh Golozar, Jill Hardin, George Hripcsak, Vojtech Huser, Hokyun Jeon, Yonghua Jing, Chi Young Jung, Benjamin Skov Kaas-Hansen, Denys Kaduk, Seamus Kent, Yeesuk Kim, Spyros Kolovos, Jennifer C. E. Lane, Hyejin Lee, Kristine E. Lynch, Rupa Makadia, Michael E. Matheny, Paras P. Mehta, Daniel R. Morales, Karthik Natarajan, Fredrik Nyberg, Anna Ostropolets, Rae Woong Park, Jimyung Park, Jose D. Posada, Albert Prats-Uribe, Gowtham Rao, Christian Reich, Yeunsook Rho, Peter Rijnbeek, Lisa M. Schilling, Martijn Schuemie, Nigam H. Shah, Azza Shoaibi, Seokyoung Song, Matthew Spotnitz, Marc A. Suchard, Joel N. Swerdel, David Vizcaya, Salvatore Volpe, Haini Wen, Andrew E. Williams, Belay B Yimer, Lin Zhang, Oleg Zhuk, Daniel Prieto-Alhambra (Lead / Corresponding author), Patrick Ryan

Population Health and Genomics

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Abstract

Comorbid conditions appear to be common among individuals hospitalised with coronavirus disease 2019 (COVID-19) but estimates of prevalence vary and little is known about the prior medication use of patients. Here, we describe the characteristics of adults hospitalised with COVID-19 and compare them with influenza patients. We include 34,128 (US: 8362, South Korea: 7341, Spain: 18,425) COVID-19 patients, summarising between 4811 and 11,643 unique aggregate characteristics. COVID-19 patients have been majority male in the US and Spain, but predominantly female in South Korea. Age profiles vary across data sources. Compared to 84,585 individuals hospitalised with influenza in 2014-19, COVID-19 patients have more typically been male, younger, and with fewer comorbidities and lower medication use. While protecting groups vulnerable to influenza is likely a useful starting point in the response to COVID-19, strategies will likely need to be broadened to reflect the particular characteristics of individuals being hospitalised with COVID-19.

Original language	English
Article number	5009
Number of pages	11
Journal	Nature Communications
Volume	11
DOIs	https://doi.org/10.1038/s41467-020-18849-z
Publication status	Published - 6 Dec 2020

Keywords

Epidemiology
Risk factors
SARS-CoV-2
Viral epidemiology

ASJC Scopus subject areas

General Physics and Astronomy
General Chemistry
General Biochemistry,Genetics and Molecular Biology

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10.1038/s41467-020-18849-zLicence: CC BY

Final Published VersionFinal published version, 2.74 MBLicence: CC BY

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Burn, E., You, S. C., Sena, A. G., Kostka, K., Abedtash, H., Abrahão, M. T. F., Alberga, A., Alghoul, H., Alser, O., Alshammari, T. M., Aragon, M., Areia, C., Banda, J. M., Cho, J., Culhane, A. C., Davydov, A., DeFalco, F. J., Duarte-Salles, T., DuVall, S., ... Ryan, P. (2020). Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study. Nature Communications, 11, Article 5009. https://doi.org/10.1038/s41467-020-18849-z

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abstract = "Comorbid conditions appear to be common among individuals hospitalised with coronavirus disease 2019 (COVID-19) but estimates of prevalence vary and little is known about the prior medication use of patients. Here, we describe the characteristics of adults hospitalised with COVID-19 and compare them with influenza patients. We include 34,128 (US: 8362, South Korea: 7341, Spain: 18,425) COVID-19 patients, summarising between 4811 and 11,643 unique aggregate characteristics. COVID-19 patients have been majority male in the US and Spain, but predominantly female in South Korea. Age profiles vary across data sources. Compared to 84,585 individuals hospitalised with influenza in 2014-19, COVID-19 patients have more typically been male, younger, and with fewer comorbidities and lower medication use. While protecting groups vulnerable to influenza is likely a useful starting point in the response to COVID-19, strategies will likely need to be broadened to reflect the particular characteristics of individuals being hospitalised with COVID-19.",

keywords = "Epidemiology, Risk factors, SARS-CoV-2, Viral epidemiology",

author = "Edward Burn and You, {Seng Chan} and Sena, {Anthony G.} and Kristin Kostka and Hamed Abedtash and Abrah{\~a}o, {Maria Tereza F.} and Amanda Alberga and Heba Alghoul and Osaid Alser and Alshammari, {Thamir M.} and Maria Aragon and Carlos Areia and Banda, {Juan M.} and Jaehyeong Cho and Culhane, {Aedin C.} and Alexander Davydov and DeFalco, {Frank J.} and Talita Duarte-Salles and Scott DuVall and Thomas Falconer and Sergio Fernandez-Bertolin and Weihua Gao and Asieh Golozar and Jill Hardin and George Hripcsak and Vojtech Huser and Hokyun Jeon and Yonghua Jing and Jung, {Chi Young} and Kaas-Hansen, {Benjamin Skov} and Denys Kaduk and Seamus Kent and Yeesuk Kim and Spyros Kolovos and Lane, {Jennifer C. E.} and Hyejin Lee and Lynch, {Kristine E.} and Rupa Makadia and Matheny, {Michael E.} and Mehta, {Paras P.} and Morales, {Daniel R.} and Karthik Natarajan and Fredrik Nyberg and Anna Ostropolets and Park, {Rae Woong} and Jimyung Park and Posada, {Jose D.} and Albert Prats-Uribe and Gowtham Rao and Christian Reich and Yeunsook Rho and Peter Rijnbeek and Schilling, {Lisa M.} and Martijn Schuemie and Shah, {Nigam H.} and Azza Shoaibi and Seokyoung Song and Matthew Spotnitz and Suchard, {Marc A.} and Swerdel, {Joel N.} and David Vizcaya and Salvatore Volpe and Haini Wen and Williams, {Andrew E.} and Yimer, {Belay B} and Lin Zhang and Oleg Zhuk and Daniel Prieto-Alhambra and Patrick Ryan",

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doi = "10.1038/s41467-020-18849-z",

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Burn, E, You, SC, Sena, AG, Kostka, K, Abedtash, H, Abrahão, MTF, Alberga, A, Alghoul, H, Alser, O, Alshammari, TM, Aragon, M, Areia, C, Banda, JM, Cho, J, Culhane, AC, Davydov, A, DeFalco, FJ, Duarte-Salles, T, DuVall, S, Falconer, T, Fernandez-Bertolin, S, Gao, W, Golozar, A, Hardin, J, Hripcsak, G, Huser, V, Jeon, H, Jing, Y, Jung, CY, Kaas-Hansen, BS, Kaduk, D, Kent, S, Kim, Y, Kolovos, S, Lane, JCE, Lee, H, Lynch, KE, Makadia, R, Matheny, ME, Mehta, PP, Morales, DR, Natarajan, K, Nyberg, F, Ostropolets, A, Park, RW, Park, J, Posada, JD, Prats-Uribe, A, Rao, G, Reich, C, Rho, Y, Rijnbeek, P, Schilling, LM, Schuemie, M, Shah, NH, Shoaibi, A, Song, S, Spotnitz, M, Suchard, MA, Swerdel, JN, Vizcaya, D, Volpe, S, Wen, H, Williams, AE, Yimer, BB, Zhang, L, Zhuk, O, Prieto-Alhambra, D & Ryan, P 2020, 'Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study', Nature Communications, vol. 11, 5009. https://doi.org/10.1038/s41467-020-18849-z

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AU - Burn, Edward

AU - You, Seng Chan

AU - Sena, Anthony G.

AU - Kostka, Kristin

AU - Abedtash, Hamed

AU - Abrahão, Maria Tereza F.

AU - Alberga, Amanda

AU - Alghoul, Heba

AU - Alser, Osaid

AU - Alshammari, Thamir M.

AU - Aragon, Maria

AU - Areia, Carlos

AU - Banda, Juan M.

AU - Cho, Jaehyeong

AU - Culhane, Aedin C.

AU - Davydov, Alexander

AU - DeFalco, Frank J.

AU - Duarte-Salles, Talita

AU - DuVall, Scott

AU - Falconer, Thomas

AU - Fernandez-Bertolin, Sergio

AU - Gao, Weihua

AU - Golozar, Asieh

AU - Hardin, Jill

AU - Hripcsak, George

AU - Huser, Vojtech

AU - Jeon, Hokyun

AU - Jing, Yonghua

AU - Jung, Chi Young

AU - Kaas-Hansen, Benjamin Skov

AU - Kaduk, Denys

AU - Kent, Seamus

AU - Kim, Yeesuk

AU - Kolovos, Spyros

AU - Lane, Jennifer C. E.

AU - Lee, Hyejin

AU - Lynch, Kristine E.

AU - Makadia, Rupa

AU - Matheny, Michael E.

AU - Mehta, Paras P.

AU - Morales, Daniel R.

AU - Natarajan, Karthik

AU - Nyberg, Fredrik

AU - Ostropolets, Anna

AU - Park, Rae Woong

AU - Park, Jimyung

AU - Posada, Jose D.

AU - Prats-Uribe, Albert

AU - Rao, Gowtham

AU - Reich, Christian

AU - Rho, Yeunsook

AU - Rijnbeek, Peter

AU - Schilling, Lisa M.

AU - Schuemie, Martijn

AU - Shah, Nigam H.

AU - Shoaibi, Azza

AU - Song, Seokyoung

AU - Spotnitz, Matthew

AU - Suchard, Marc A.

AU - Swerdel, Joel N.

AU - Vizcaya, David

AU - Volpe, Salvatore

AU - Wen, Haini

AU - Williams, Andrew E.

AU - Yimer, Belay B

AU - Zhang, Lin

AU - Zhuk, Oleg

AU - Prieto-Alhambra, Daniel

AU - Ryan, Patrick

PY - 2020/12/6

Y1 - 2020/12/6

N2 - Comorbid conditions appear to be common among individuals hospitalised with coronavirus disease 2019 (COVID-19) but estimates of prevalence vary and little is known about the prior medication use of patients. Here, we describe the characteristics of adults hospitalised with COVID-19 and compare them with influenza patients. We include 34,128 (US: 8362, South Korea: 7341, Spain: 18,425) COVID-19 patients, summarising between 4811 and 11,643 unique aggregate characteristics. COVID-19 patients have been majority male in the US and Spain, but predominantly female in South Korea. Age profiles vary across data sources. Compared to 84,585 individuals hospitalised with influenza in 2014-19, COVID-19 patients have more typically been male, younger, and with fewer comorbidities and lower medication use. While protecting groups vulnerable to influenza is likely a useful starting point in the response to COVID-19, strategies will likely need to be broadened to reflect the particular characteristics of individuals being hospitalised with COVID-19.

AB - Comorbid conditions appear to be common among individuals hospitalised with coronavirus disease 2019 (COVID-19) but estimates of prevalence vary and little is known about the prior medication use of patients. Here, we describe the characteristics of adults hospitalised with COVID-19 and compare them with influenza patients. We include 34,128 (US: 8362, South Korea: 7341, Spain: 18,425) COVID-19 patients, summarising between 4811 and 11,643 unique aggregate characteristics. COVID-19 patients have been majority male in the US and Spain, but predominantly female in South Korea. Age profiles vary across data sources. Compared to 84,585 individuals hospitalised with influenza in 2014-19, COVID-19 patients have more typically been male, younger, and with fewer comorbidities and lower medication use. While protecting groups vulnerable to influenza is likely a useful starting point in the response to COVID-19, strategies will likely need to be broadened to reflect the particular characteristics of individuals being hospitalised with COVID-19.

KW - Epidemiology

KW - Risk factors

KW - SARS-CoV-2

KW - Viral epidemiology

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DO - 10.1038/s41467-020-18849-z

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SN - 2041-1723

VL - 11

JO - Nature Communications

JF - Nature Communications

M1 - 5009

ER -

Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study

Abstract

Keywords

ASJC Scopus subject areas

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Approaches for Creating Clinical Evidence of Treatment Effects in Routine Populations Excluded from Trials (ACCEPT) (Clinical Research Career Development Fellowship)

Morales, Daniel

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Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

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Approaches for Creating Clinical Evidence of Treatment Effects in Routine Populations Excluded from Trials (ACCEPT) (Clinical Research Career Development Fellowship)

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Morales, Daniel

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