Defects in the origin licensing checkpoint stresses cells exiting G0

J. Julian Blow

doi:10.1083/jcb.201905181

Defects in the origin licensing checkpoint stresses cells exiting G0

J. Julian Blow (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

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Abstract

The full licensing of replication origins in late G1 is normally enforced by the licensing checkpoint. In this issue, Matson et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902143) show that this checkpoint is inoperative in cells exiting from G0, resulting in incomplete origin licensing and consequent replicative stress.

Original language	English
Pages (from-to)	2080-2081
Number of pages	2
Journal	Journal of Cell Biology
Volume	218
Issue number	7
Early online date	11 Jun 2019
DOIs	https://doi.org/10.1083/jcb.201905181
Publication status	Published - 1 Jul 2019

ASJC Scopus subject areas

Cell Biology

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10.1083/jcb.201905181Licence: CC BY-NC-SA

Final Published VersionFinal published version, 656 KBLicence: CC BY-NC-SA

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title = "Defects in the origin licensing checkpoint stresses cells exiting G0",

abstract = "The full licensing of replication origins in late G1 is normally enforced by the licensing checkpoint. In this issue, Matson et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902143) show that this checkpoint is inoperative in cells exiting from G0, resulting in incomplete origin licensing and consequent replicative stress. ",

author = "Blow, {J. Julian}",

note = "Funding: Wellcome Trust WT096598MA",

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AB - The full licensing of replication origins in late G1 is normally enforced by the licensing checkpoint. In this issue, Matson et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902143) show that this checkpoint is inoperative in cells exiting from G0, resulting in incomplete origin licensing and consequent replicative stress.

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Defects in the origin licensing checkpoint stresses cells exiting G0

Abstract

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Understanding the Cellular Response to Replication Inhibition (Senior Investigator Award)

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Defects in the origin licensing checkpoint stresses cells exiting G0

Abstract

ASJC Scopus subject areas

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Projects

Understanding the Cellular Response to Replication Inhibition (Senior Investigator Award)

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