Keyphrases
Knock-in Mouse Model
100%
Cytochrome P450 1A2 (CYP1A2)
100%
Cytochrome P450 1A1 (CYP1A1)
100%
Drug Metabolism
100%
Humanized
100%
Metabolism
27%
Relative Contribution
18%
Liver
18%
Substrate Specificity
18%
Cytochrome P450 (CYP450)
18%
Gene Locus
18%
Enzyme Kinetics
18%
Tetrachlorodibenzodioxin
18%
Inhibitor Concentration
9%
Relative Role
9%
Prediction Accuracy
9%
Lung
9%
Human Enzymes
9%
Selective Inhibitor
9%
Quinidine
9%
Kidney
9%
Small Intestine
9%
Humanized Mice
9%
Carcinogenicity
9%
Hepatic Metabolism
9%
Microsomal Fraction
9%
Metabolism in Vivo
9%
Methoxy
9%
Physiologically-based Pharmacokinetic Model
9%
Differential Inhibition
9%
Mouse in Vivo
9%
Enzyme Concentration
9%
Kinetic Approach
9%
Probe Compound
9%
Substrate Enzyme
9%
Pharmacology, Toxicology and Pharmaceutical Science
Knockout Mouse
100%
CYP1A2
100%
Cytochrome P450 1A1
100%
Drug Metabolism
100%
Substrate Specificity
28%
Enzyme Kinetics
28%
2,3,7,8-Tetrachlorodibenzodioxin
28%
Quinidine
14%
Cytochrome P450
14%
Cytochrome
14%
Carcinogenicity
14%
Cytochrome P450 1A
14%
Pharmacokinetics
14%