Deformable registration of retinal fluorescein angiogram sequences using vasculature structures

Adria Perez-Rovira, Emanuele Trucco, Peter Wilson, Jiang Liu

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    6 Citations (Scopus)


    State-of-the-art deformable registration algorithms do not perform as well with FA sequences because they are designed to deal with changes of content appearance (e. g., due to different sensors imaging the same organs) but not with content changes, which occur throughout a FA sequence as different portions or the vascular structure are visible (perfused) in different frames. This paper presents a frame-to-frame registration algorithm for ultra-wide-field-of-view (UWFV) fluorescein angiograms (FA) of the retina, based on deformable alignment of the retinal vasculature structure. Comparative experiments on an initial set of UWFV FAs indicate that, thanks to its specialization, our technique outperforms one of the best state-of-the-art methods for multimodal image registration when dealing with the demanding characteristics of the UWFV FA sequences.

    Original languageEnglish
    Title of host publicationEngineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE
    Place of PublicationNew York
    PublisherIEEE Computer Society
    Number of pages4
    ISBN (Print)9781424441235
    Publication statusPublished - 2010
    Event32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Buenos Aires Sheraton Hotel, Buenos Aries, Argentina
    Duration: 31 Aug 20104 Sep 2010


    Conference32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    Abbreviated titleEMBC'10
    CityBuenos Aries
    Internet address



    Cite this