Deletion of PKCε selectively enhances the amplifying pathways of glucose-stimulated insulin secretion via increased lipolysis in mouse β-cells

Keyphrases

• Protein Kinase 100%
• Glucose-stimulated Insulin Secretion 100%
• Lipolysis 100%
• Mouse Cells 100%
• Amplifying Pathway 100%
• Lipids 55%
• Palmitate 33%
• Islet 33%
• Type 2 Diabetes Mellitus (T2DM) 22%
• Insulin Secretion 22%
• Esterification 22%
• Lipase Activity 22%
• Gene Expression 11%
• Ablation 11%
• Interacting Proteins 11%
• Knock-in Mouse Model 11%
• Protein Kinase C Isoforms 11%
• Ca2+ 11%
• Therapeutic Potential 11%
• K+ Channels 11%
• Triglycerides 11%
• Lipid Levels 11%
• Glucose Homeostasis 11%
• Ca2+ Influx 11%
• Acute Treatment 11%
• Knockout Cells 11%
• Murine Cells 11%
• Lipase Gene 11%
• Lipotoxicity 11%
• Secretory Dysfunction 11%
• Triglyceride Lipase 11%
• Lipase Inhibitor 11%
• Orlistat 11%

Biochemistry, Genetics and Molecular Biology

• Protein Kinase C 100%
• Lipolysis 100%
• Insulin Release 100%
• Lipid 45%
• Triacylglycerol Lipase 27%
• Pancreatic Lipase 27%
• Palmitic Acid 27%
• Esterification 18%
• Gene Expression 9%
• Adenosine Triphosphate 9%
• Isoform 9%
• Upregulation 9%
• Knockout Mouse 9%
• Glucose Homeostasis 9%
• Potassium Channel 9%
• Lipid Level 9%
• Triglyceride 9%
• Lipotoxicity 9%
• Triglyceride Lipase 9%