Deletion of the Trypanosoma brucei superoxide dismutase gene sodb1 increases sensitivity to nifurtimox and benznidazole

S. Radhika Prathalingham, Shane R. Wilkinson, David Horn, John M. Kelly

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

It has been more than 25 years since it was first reported that nifurtimox and benznidazole promote superoxide production in trypanosomes. However, there has been no direct evidence of an association between the drug-induced free radicals and trypanocidal activity. Here, we identify a superoxide dismutase required to protect Trypanosoma brucei from drug-generated superoxide.

Original languageEnglish
Pages (from-to)755-758
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume51
Issue number2
DOIs
Publication statusPublished - Feb 2007

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