Abstract
It has been more than 25 years since it was first reported that nifurtimox and benznidazole promote superoxide production in trypanosomes. However, there has been no direct evidence of an association between the drug-induced free radicals and trypanocidal activity. Here, we identify a superoxide dismutase required to protect Trypanosoma brucei from drug-generated superoxide.
Original language | English |
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Pages (from-to) | 755-758 |
Number of pages | 4 |
Journal | Antimicrobial Agents and Chemotherapy |
Volume | 51 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 2007 |
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases