Deletion of the Trypanosoma brucei superoxide dismutase gene sodb1 increases sensitivity to nifurtimox and benznidazole

S. Radhika Prathalingham; Shane R. Wilkinson; David Horn; John M. Kelly

doi:10.1128/AAC.01360-06

Deletion of the Trypanosoma brucei superoxide dismutase gene sodb1 increases sensitivity to nifurtimox and benznidazole

S. Radhika Prathalingham
, Shane R. Wilkinson
, David Horn
, John M. Kelly

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

It has been more than 25 years since it was first reported that nifurtimox and benznidazole promote superoxide production in trypanosomes. However, there has been no direct evidence of an association between the drug-induced free radicals and trypanocidal activity. Here, we identify a superoxide dismutase required to protect Trypanosoma brucei from drug-generated superoxide.

Original language	English
Pages (from-to)	755-758
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	51
Issue number	2
DOIs	https://doi.org/10.1128/AAC.01360-06
Publication status	Published - Feb 2007

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.01360-06

Cite this

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abstract = "It has been more than 25 years since it was first reported that nifurtimox and benznidazole promote superoxide production in trypanosomes. However, there has been no direct evidence of an association between the drug-induced free radicals and trypanocidal activity. Here, we identify a superoxide dismutase required to protect Trypanosoma brucei from drug-generated superoxide.",

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AU - Kelly, John M.

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Deletion of the Trypanosoma brucei superoxide dismutase gene sodb1 increases sensitivity to nifurtimox and benznidazole

Abstract

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