Dementia with Lewy bodies: An update and outlook

Tiago Fleming Outeiro (Lead / Corresponding author), David J. Koss, Daniel Erskine, Lauren Walker, Marzena Kurzawa-Akanbi, David Burn, Paul Donaghy, Christopher Morris, John Paul Taylor, Alan Thomas, Johannes Attems, Ian McKeith (Lead / Corresponding author)

    Research output: Contribution to journalReview articlepeer-review

    212 Citations (Scopus)
    27 Downloads (Pure)

    Abstract

    Dementia with Lewy bodies (DLB) is an age-associated neurodegenerative disorder producing progressive cognitive decline that interferes with normal life and daily activities. Neuropathologically, DLB is characterised by the accumulation of aggregated α-synuclein protein in Lewy bodies and Lewy neurites, similar to Parkinson's disease (PD). Extrapyramidal motor features characteristic of PD, are common in DLB patients, but are not essential for the clinical diagnosis of DLB. Since many PD patients develop dementia as disease progresses, there has been controversy about the separation of DLB from PD dementia (PDD) and consensus reports have put forward guidelines to assist clinicians in the identification and management of both syndromes. Here, we present basic concepts and definitions, based on our current understanding, that should guide the community to address open questions that will, hopefully, lead us towards improved diagnosis and novel therapeutic strategies for DLB and other synucleinopathies.

    Original languageEnglish
    Article number5
    Number of pages18
    JournalMolecular Neurodegeneration
    Volume14
    DOIs
    Publication statusPublished - 21 Jan 2019

    Keywords

    • Alpha-synuclein
    • Alzheimer's disease
    • Biomarkers
    • Dementia
    • Dementia with Lewy bodies

    ASJC Scopus subject areas

    • Molecular Biology
    • Clinical Neurology
    • Cellular and Molecular Neuroscience

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