Demyelination models in the spinal cord

Paul A. Felts, Damineh Morsali, Mona Sadeghian, Marija Sajic, Kenneth J. Smith

    Research output: Chapter in Book/Report/Conference proceedingOther chapter contribution


    Disruption of axonal conduction within the central nervous system has obvious, negative consequences on numerous functions, including the ability to execute movement successfully. One important cause of axonal conduction deficits is primary demyelination, that is, the loss of the myelin sheaths but sparing of the axons which they surround. Such demyelination leads to conduction deficits ranging from action potential slowing and loss of transmission fidelity, to conduction block, and this latter, most severe consequence is almost inevitably the first consequence of the loss of a whole internode(s) of myelin. Several methods have been developed to induce primary demyelination in the spinal cord and some of the more common of these will be discussed in this chapter.
    Original languageEnglish
    Title of host publicationNeuromethods
    Number of pages17
    Publication statusPublished - 1 Jan 2011


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