Depth profiling of photothermal compound concentrations using phase sensitive optical coherence tomography

Guangying Guan, Roberto Reif, Zhihong Huang, Ruikang K Wang

    Research output: Contribution to journalArticle

    25 Citations (Scopus)

    Abstract

    A model that describes the concentration of photothermal (light-to-heat converters) compounds as a function of depth in a turbid medium is developed. The system consists of a pump laser (808 nm modulated at 400 Hz), which heats a photothermal compound, and a phase sensitive spectral domain optical coherence tomography system, which detects the changes in the optical path length of the sample induced by the temperature increase. The model is theoretically derived and the coefficients are empirically determined using solid homogeneous gel phantoms. The model is validated by reconstructing the concentration of a photothermal compound in thick single and double layer solid phantoms.
    Original languageEnglish
    Article number126003
    Number of pages9
    JournalJournal of Biomedical Optics
    Volume16
    Issue number12
    DOIs
    Publication statusPublished - 28 Nov 2011

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  • Student Theses

    Micro-motion detection by optical coherence tomography (OCT) and its clinical applications

    Author: Guan, G., 2015

    Supervisor: Huang, Z. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

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