Design and synthesis of an array of selective androgen receptor modulators

Ryan P. Trump; Jean-Baptiste E. Blanc; Eugene L. Stewart; Peter J. Brown; Matilde Caivano; David W. Gray; William J. Hoekstra; Timothy M. Willson; Bajin Han; Philip Turnbull

doi:10.1021/cc060096e

Design and synthesis of an array of selective androgen receptor modulators

Ryan P. Trump, Jean-Baptiste E. Blanc, Eugene L. Stewart, Peter J. Brown, Matilde Caivano, David W. Gray, William J. Hoekstra, Timothy M. Willson, Bajin Han, Philip Turnbull

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

We describe the design, using shape comparison and fast docking computer algorithms, and rapid parallel synthesis of a 1300 member array based on GSK7721, a 4-aminobenzonitrile androgen receptor (AR) antagonist identified by focused screening of the GSK compound collection. The array yielded 352 submicromolar and 17 subnanomolar AR agonists as measured by a cell-based reporter gene functional assay. The rapid synthesis of a large number of active compounds provided valuable information in the optimization of AR modulators, which may be useful in treating androgen deficiency in aging males.

Original language	English
Pages (from-to)	107-14
Number of pages	8
Journal	Journal of Combinatorial Chemistry
Volume	9
Issue number	1
DOIs	https://doi.org/10.1021/cc060096e
Publication status	Published - 2007

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10.1021/cc060096e

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abstract = "We describe the design, using shape comparison and fast docking computer algorithms, and rapid parallel synthesis of a 1300 member array based on GSK7721, a 4-aminobenzonitrile androgen receptor (AR) antagonist identified by focused screening of the GSK compound collection. The array yielded 352 submicromolar and 17 subnanomolar AR agonists as measured by a cell-based reporter gene functional assay. The rapid synthesis of a large number of active compounds provided valuable information in the optimization of AR modulators, which may be useful in treating androgen deficiency in aging males.",

author = "Trump, {Ryan P.} and Blanc, {Jean-Baptiste E.} and Stewart, {Eugene L.} and Brown, {Peter J.} and Matilde Caivano and Gray, {David W.} and Hoekstra, {William J.} and Willson, {Timothy M.} and Bajin Han and Philip Turnbull",

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AU - Blanc, Jean-Baptiste E.

AU - Stewart, Eugene L.

AU - Brown, Peter J.

AU - Caivano, Matilde

AU - Gray, David W.

AU - Hoekstra, William J.

AU - Willson, Timothy M.

AU - Han, Bajin

AU - Turnbull, Philip

PY - 2007

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AB - We describe the design, using shape comparison and fast docking computer algorithms, and rapid parallel synthesis of a 1300 member array based on GSK7721, a 4-aminobenzonitrile androgen receptor (AR) antagonist identified by focused screening of the GSK compound collection. The array yielded 352 submicromolar and 17 subnanomolar AR agonists as measured by a cell-based reporter gene functional assay. The rapid synthesis of a large number of active compounds provided valuable information in the optimization of AR modulators, which may be useful in treating androgen deficiency in aging males.

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Design and synthesis of an array of selective androgen receptor modulators

Abstract

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