Design and synthesis of sarolaner, a novel, once-a-month, oral isoxazoline for the control of fleas and ticks on dogs

Michael P. Curtis; Valerie Vaillancourt; Richard M. Goodwin; Nathan A. L. Chubb; William Howson; Tom L. McTier; Aleah Pullins; Erich W. Zinser; Patrick F. M. Meeus; Debra J. Woods; Laura Hedges; Tim Stuk; Jeffrey E. Price; Jason D. Koch; Sanjay R. Menon

doi:10.1016/j.bmcl.2016.02.027

Design and synthesis of sarolaner, a novel, once-a-month, oral isoxazoline for the control of fleas and ticks on dogs

Michael P. Curtis, Valerie Vaillancourt, Richard M. Goodwin, Nathan A. L. Chubb, William Howson, Tom L. McTier, Aleah Pullins, Erich W. Zinser, Patrick F. M. Meeus, Debra J. Woods, Laura Hedges, Tim Stuk, Jeffrey E. Price, Jason D. Koch, Sanjay R. Menon (Lead / Corresponding author)

Drug Discovery Unit

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Over the last decade, the isoxazoline motif has become the intense focus of crop protection and animal health companies in their search for novel pesticides and ectoparasiticides. Herein we report the discovery of sarolaner, a proprietary, optimized-for-animal health use isoxazoline, for once-a-month oral treatment of flea and tick infestation on dogs.

Original language	English
Pages (from-to)	1831-1835
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	26
Issue number	7
Early online date	12 Feb 2016
DOIs	https://doi.org/10.1016/j.bmcl.2016.02.027
Publication status	Published - 1 Apr 2016

Keywords

Ectoparasiticide
Isoxazoline
Oral flea and tick agent
Sarolaner

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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Curtis, M. P., Vaillancourt, V., Goodwin, R. M., Chubb, N. A. L., Howson, W., McTier, T. L., Pullins, A., Zinser, E. W., Meeus, P. F. M., Woods, D. J., Hedges, L., Stuk, T., Price, J. E., Koch, J. D., & Menon, S. R. (2016). Design and synthesis of sarolaner, a novel, once-a-month, oral isoxazoline for the control of fleas and ticks on dogs. Bioorganic and Medicinal Chemistry Letters, 26(7), 1831-1835. https://doi.org/10.1016/j.bmcl.2016.02.027

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title = "Design and synthesis of sarolaner, a novel, once-a-month, oral isoxazoline for the control of fleas and ticks on dogs",

abstract = "Over the last decade, the isoxazoline motif has become the intense focus of crop protection and animal health companies in their search for novel pesticides and ectoparasiticides. Herein we report the discovery of sarolaner, a proprietary, optimized-for-animal health use isoxazoline, for once-a-month oral treatment of flea and tick infestation on dogs.",

keywords = "Ectoparasiticide, Isoxazoline, Oral flea and tick agent, Sarolaner",

author = "Curtis, {Michael P.} and Valerie Vaillancourt and Goodwin, {Richard M.} and Chubb, {Nathan A. L.} and William Howson and McTier, {Tom L.} and Aleah Pullins and Zinser, {Erich W.} and Meeus, {Patrick F. M.} and Woods, {Debra J.} and Laura Hedges and Tim Stuk and Price, {Jeffrey E.} and Koch, {Jason D.} and Menon, {Sanjay R.}",

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doi = "10.1016/j.bmcl.2016.02.027",

language = "English",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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Curtis, MP, Vaillancourt, V, Goodwin, RM, Chubb, NAL, Howson, W, McTier, TL, Pullins, A, Zinser, EW, Meeus, PFM, Woods, DJ, Hedges, L, Stuk, T, Price, JE, Koch, JD & Menon, SR 2016, 'Design and synthesis of sarolaner, a novel, once-a-month, oral isoxazoline for the control of fleas and ticks on dogs', Bioorganic and Medicinal Chemistry Letters, vol. 26, no. 7, pp. 1831-1835. https://doi.org/10.1016/j.bmcl.2016.02.027

TY - JOUR

T1 - Design and synthesis of sarolaner, a novel, once-a-month, oral isoxazoline for the control of fleas and ticks on dogs

AU - Curtis, Michael P.

AU - Vaillancourt, Valerie

AU - Goodwin, Richard M.

AU - Chubb, Nathan A. L.

AU - Howson, William

AU - McTier, Tom L.

AU - Pullins, Aleah

AU - Zinser, Erich W.

AU - Meeus, Patrick F. M.

AU - Woods, Debra J.

AU - Hedges, Laura

AU - Stuk, Tim

AU - Price, Jeffrey E.

AU - Koch, Jason D.

AU - Menon, Sanjay R.

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Over the last decade, the isoxazoline motif has become the intense focus of crop protection and animal health companies in their search for novel pesticides and ectoparasiticides. Herein we report the discovery of sarolaner, a proprietary, optimized-for-animal health use isoxazoline, for once-a-month oral treatment of flea and tick infestation on dogs.

AB - Over the last decade, the isoxazoline motif has become the intense focus of crop protection and animal health companies in their search for novel pesticides and ectoparasiticides. Herein we report the discovery of sarolaner, a proprietary, optimized-for-animal health use isoxazoline, for once-a-month oral treatment of flea and tick infestation on dogs.

KW - Ectoparasiticide

KW - Isoxazoline

KW - Oral flea and tick agent

KW - Sarolaner

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M3 - Article

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AN - SCOPUS:85006168484

SN - 0960-894X

VL - 26

SP - 1831

EP - 1835

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 7

ER -

Design and synthesis of sarolaner, a novel, once-a-month, oral isoxazoline for the control of fleas and ticks on dogs

Abstract

Keywords

ASJC Scopus subject areas

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