Design and synthesis of sarolaner, a novel, once-a-month, oral isoxazoline for the control of fleas and ticks on dogs

Michael P. Curtis, Valerie Vaillancourt, Richard M. Goodwin, Nathan A. L. Chubb, William Howson, Tom L. McTier, Aleah Pullins, Erich W. Zinser, Patrick F. M. Meeus, Debra J. Woods, Laura Hedges, Tim Stuk, Jeffrey E. Price, Jason D. Koch, Sanjay R. Menon (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Over the last decade, the isoxazoline motif has become the intense focus of crop protection and animal health companies in their search for novel pesticides and ectoparasiticides. Herein we report the discovery of sarolaner, a proprietary, optimized-for-animal health use isoxazoline, for once-a-month oral treatment of flea and tick infestation on dogs.

Original languageEnglish
Pages (from-to)1831-1835
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume26
Issue number7
Early online date12 Feb 2016
DOIs
Publication statusPublished - 1 Apr 2016

Keywords

  • Ectoparasiticide
  • Isoxazoline
  • Oral flea and tick agent
  • Sarolaner

Fingerprint Dive into the research topics of 'Design and synthesis of sarolaner, a novel, once-a-month, oral isoxazoline for the control of fleas and ticks on dogs'. Together they form a unique fingerprint.

Cite this