Design, synthesis and evaluation of 2,4-diaminoquinazolines as inhibitors of trypanosomal and leishmanial dihydrofolate reductase

Soghra Khabnadideh, Didier Pez, Alexander Musso, Reto Brun, Luis M. Ruiz Perez, Dolores Gonzalez-Pacanowska, Ian H. Gilbert

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    This paper describes the design, synthesis and evaluation of a series of 2,4-diaminoquinazolines as inhibitors of leishmanial and trypanosomal dihydrofolate reductase. Compounds were designed by a generating virtual library of compounds and docking them into the enzyme active site. Following their synthesis, they were found to be potent and selective inhibitors of leishmanial dihydrofolate reductase. The compounds were also found to have potent activity against Trypanosoma brucei rhodesiense, a causative organism of African trypanosomiasis and also against Trypanosoma cruzi, the causative organism of Chagas disease. There was significantly lower activity against Leishmania donovani, one of the causative organisms of leishmaniasis. (c) 2005 Elsevier Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)2637-2649
    Number of pages13
    JournalBioorganic & Medicinal Chemistry
    Issue number7
    Publication statusPublished - 1 Apr 2005

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