Design, synthesis, and evaluation of inhibitors of trypanosomal and leishmanial dihydrofolate reductase

Keyphrases

• Human Enzymes 100%
• Methylenetetrahydrofolate Reductase (MTHFR) 100%
• Leishmania 50%
• Benzyl 50%
• Trypanosome 50%
• Structural Information 50%
• In Vivo Activity 50%
• African Trypanosomiasis 50%
• Clinically Significant 50%
• Selective Drugs 50%
• Enzyme Active Site 50%
• Enzyme Assay 50%
• 2,4-Diaminopyrimidine 50%
• Drug Design 50%
• Assay Data 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Protozoon 100%
• Dihydrofolate Reductase 100%
• African Trypanosomiasis 50%
• Leishmania 50%
• Trypanosoma 50%
• Drug Development 50%
• 2,4 Diamino 5 Benzylpyrimidine 50%