Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase

Orla K. McCarthy; Alessandro Schipani; Alex Musso Buendia; Luis M. Ruiz-Perez; Marcel Kaiser; Reto Brun; Dolores Gonzalez  Pacanowska; Ian H  Gilbert

doi:10.1016/j.bmcl.2006.04.027

Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase

Orla K. McCarthy, Alessandro Schipani, Alex Musso Buendia, Luis M. Ruiz-Perez, Marcel Kaiser, Reto Brun, Dolores Gonzalez Pacanowska, Ian H Gilbert

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Potential inhibitors of the Trypanosoma cruzi dUTP nucleotidohydrolase were docked into the enzyme using the program FlexX. Compounds that docked selectively were then selected and synthesized using solid phase methodology, giving rise to a novel library of amino acid uracil acetamide compounds which were evaluated for enzyme inhibition and anti-parasitic activity. (c) 2006 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	3809-3812
Number of pages	4
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	16
Issue number	14
DOIs	https://doi.org/10.1016/j.bmcl.2006.04.027
Publication status	Published - 15 Jul 2006

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10.1016/j.bmcl.2006.04.027

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title = "Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase",

abstract = "Potential inhibitors of the Trypanosoma cruzi dUTP nucleotidohydrolase were docked into the enzyme using the program FlexX. Compounds that docked selectively were then selected and synthesized using solid phase methodology, giving rise to a novel library of amino acid uracil acetamide compounds which were evaluated for enzyme inhibition and anti-parasitic activity. (c) 2006 Elsevier Ltd. All rights reserved.",

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AU - McCarthy, Orla K.

AU - Schipani, Alessandro

AU - Buendia, Alex Musso

AU - Ruiz-Perez, Luis M.

AU - Kaiser, Marcel

AU - Brun, Reto

AU - Pacanowska, Dolores Gonzalez

AU - Gilbert, Ian H

PY - 2006/7/15

Y1 - 2006/7/15

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AB - Potential inhibitors of the Trypanosoma cruzi dUTP nucleotidohydrolase were docked into the enzyme using the program FlexX. Compounds that docked selectively were then selected and synthesized using solid phase methodology, giving rise to a novel library of amino acid uracil acetamide compounds which were evaluated for enzyme inhibition and anti-parasitic activity. (c) 2006 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.bmcl.2006.04.027

DO - 10.1016/j.bmcl.2006.04.027

M3 - Article

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VL - 16

SP - 3809

EP - 3812

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 14

ER -

Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase

Abstract

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