Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase

Orla K. McCarthy, Alessandro Schipani, Alex Musso Buendia, Luis M. Ruiz-Perez, Marcel Kaiser, Reto Brun, Dolores Gonzalez Pacanowska, Ian H Gilbert

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    15 Citations (Scopus)

    Abstract

    Potential inhibitors of the Trypanosoma cruzi dUTP nucleotidohydrolase were docked into the enzyme using the program FlexX. Compounds that docked selectively were then selected and synthesized using solid phase methodology, giving rise to a novel library of amino acid uracil acetamide compounds which were evaluated for enzyme inhibition and anti-parasitic activity. (c) 2006 Elsevier Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)3809-3812
    Number of pages4
    JournalBioorganic & Medicinal Chemistry Letters
    Volume16
    Issue number14
    DOIs
    Publication statusPublished - 15 Jul 2006

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