Design, synthesis and evaluation of peptide libraries as potential anti-HIV compounds, via inhibition of gp120/cell membrane interactions, using the gp120/cd4/fab17 crystal structure

Cyrille Boussard; Valerie E. Doyle; Naheed Mahmood; Thomas Klimkait; Martyn Pritchard; Ian H.  Gilbert

doi:10.1016/S0223-5234(02)01412-5

Design, synthesis and evaluation of peptide libraries as potential anti-HIV compounds, via inhibition of gp120/cell membrane interactions, using the gp120/cd4/fab17 crystal structure

Cyrille Boussard, Valerie E. Doyle, Naheed Mahmood, Thomas Klimkait, Martyn Pritchard, Ian H. Gilbert

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

The crystal structure of a gp120/CD4/Fab17b complex was analysed leading to the design of several peptide libraries in the hope of obtaining novel gp120/cell membrane receptor interaction inhibitors, especially inhibitors of gp120/CD4 and gp120/chemokine receptor interactions. Syntheses of tri- and tetra- and pentapeptides were performed via a solid phase synthesis methodology using a Rink Amide MBHA resin and a Fmoc strategy giving C-terminal amide form peptides. Compounds were assayed against C8166 cells infected by HIV-1 IIIB and screened using a gp120 binding assay and the FIGS reporter gene assay. (C) 2002 Published by Editions scientifiques et medicales Elsevier SAS.

Original language	English
Pages (from-to)	883-890
Number of pages	8
Journal	European Journal of Medicinal Chemistry
Volume	37
Issue number	11
DOIs	https://doi.org/10.1016/S0223-5234(02)01412-5
Publication status	Published - Nov 2002

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0223-5234(02)01412-5

Cite this

Boussard, C., Doyle, V. E., Mahmood, N., Klimkait, T., Pritchard, M., & Gilbert, I. H. (2002). Design, synthesis and evaluation of peptide libraries as potential anti-HIV compounds, via inhibition of gp120/cell membrane interactions, using the gp120/cd4/fab17 crystal structure. European Journal of Medicinal Chemistry, 37(11), 883-890. https://doi.org/10.1016/S0223-5234(02)01412-5

@article{c5e35c05ce474409bf0d438d645013c9,

title = "Design, synthesis and evaluation of peptide libraries as potential anti-HIV compounds, via inhibition of gp120/cell membrane interactions, using the gp120/cd4/fab17 crystal structure",

abstract = "The crystal structure of a gp120/CD4/Fab17b complex was analysed leading to the design of several peptide libraries in the hope of obtaining novel gp120/cell membrane receptor interaction inhibitors, especially inhibitors of gp120/CD4 and gp120/chemokine receptor interactions. Syntheses of tri- and tetra- and pentapeptides were performed via a solid phase synthesis methodology using a Rink Amide MBHA resin and a Fmoc strategy giving C-terminal amide form peptides. Compounds were assayed against C8166 cells infected by HIV-1 IIIB and screened using a gp120 binding assay and the FIGS reporter gene assay. (C) 2002 Published by Editions scientifiques et medicales Elsevier SAS.",

author = "Cyrille Boussard and Doyle, \{Valerie E.\} and Naheed Mahmood and Thomas Klimkait and Martyn Pritchard and Gilbert, \{Ian H.\}",

year = "2002",

month = nov,

doi = "10.1016/S0223-5234(02)01412-5",

language = "English",

volume = "37",

pages = "883--890",

journal = "European Journal of Medicinal Chemistry",

issn = "0223-5234",

publisher = "Elsevier",

number = "11",

}

Boussard, C, Doyle, VE, Mahmood, N, Klimkait, T, Pritchard, M & Gilbert, IH 2002, 'Design, synthesis and evaluation of peptide libraries as potential anti-HIV compounds, via inhibition of gp120/cell membrane interactions, using the gp120/cd4/fab17 crystal structure', European Journal of Medicinal Chemistry, vol. 37, no. 11, pp. 883-890. https://doi.org/10.1016/S0223-5234(02)01412-5

Design, synthesis and evaluation of peptide libraries as potential anti-HIV compounds, via inhibition of gp120/cell membrane interactions, using the gp120/cd4/fab17 crystal structure. / Boussard, Cyrille; Doyle, Valerie E.; Mahmood, Naheed et al.
In: European Journal of Medicinal Chemistry, Vol. 37, No. 11, 11.2002, p. 883-890.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Design, synthesis and evaluation of peptide libraries as potential anti-HIV compounds, via inhibition of gp120/cell membrane interactions, using the gp120/cd4/fab17 crystal structure

AU - Boussard, Cyrille

AU - Doyle, Valerie E.

AU - Mahmood, Naheed

AU - Klimkait, Thomas

AU - Pritchard, Martyn

AU - Gilbert, Ian H.

PY - 2002/11

Y1 - 2002/11

N2 - The crystal structure of a gp120/CD4/Fab17b complex was analysed leading to the design of several peptide libraries in the hope of obtaining novel gp120/cell membrane receptor interaction inhibitors, especially inhibitors of gp120/CD4 and gp120/chemokine receptor interactions. Syntheses of tri- and tetra- and pentapeptides were performed via a solid phase synthesis methodology using a Rink Amide MBHA resin and a Fmoc strategy giving C-terminal amide form peptides. Compounds were assayed against C8166 cells infected by HIV-1 IIIB and screened using a gp120 binding assay and the FIGS reporter gene assay. (C) 2002 Published by Editions scientifiques et medicales Elsevier SAS.

AB - The crystal structure of a gp120/CD4/Fab17b complex was analysed leading to the design of several peptide libraries in the hope of obtaining novel gp120/cell membrane receptor interaction inhibitors, especially inhibitors of gp120/CD4 and gp120/chemokine receptor interactions. Syntheses of tri- and tetra- and pentapeptides were performed via a solid phase synthesis methodology using a Rink Amide MBHA resin and a Fmoc strategy giving C-terminal amide form peptides. Compounds were assayed against C8166 cells infected by HIV-1 IIIB and screened using a gp120 binding assay and the FIGS reporter gene assay. (C) 2002 Published by Editions scientifiques et medicales Elsevier SAS.

U2 - 10.1016/S0223-5234(02)01412-5

DO - 10.1016/S0223-5234(02)01412-5

M3 - Article

SN - 0223-5234

VL - 37

SP - 883

EP - 890

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

IS - 11

ER -

Design, synthesis and evaluation of peptide libraries as potential anti-HIV compounds, via inhibition of gp120/cell membrane interactions, using the gp120/cd4/fab17 crystal structure

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this