Design, synthesis and evaluation of potential inhibitors of HIV gp120-CD4 interactions

Cyrille  Boussard; Thomas Klimkait; Naheed Mahmood; Martin  Pritchard; Ian H.  Gilbert

doi:10.1016/j.bmcl.2004.02.091

Design, synthesis and evaluation of potential inhibitors of HIV gp120-CD4 interactions

Cyrille Boussard, Thomas Klimkait, Naheed Mahmood, Martin Pritchard, Ian H. Gilbert

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

This paper describes an approach to prevent HIV-cell fusion by disrupting the interaction between HIV protein gp120 and CD4 receptor. The CD4 residues Phe43 and Arg59 make important interactions with gp120. Small molecule analogues were made to mimic the crucial features of these residues. The analogues were assayed using a cellular 'FIGS' assay to measure inhibition of cell fusion and caused some inhibition. (C) 2004 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	2673-2676
Number of pages	4
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	14
Issue number	10
DOIs	https://doi.org/10.1016/j.bmcl.2004.02.091
Publication status	Published - 17 May 2004

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10.1016/j.bmcl.2004.02.091

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abstract = "This paper describes an approach to prevent HIV-cell fusion by disrupting the interaction between HIV protein gp120 and CD4 receptor. The CD4 residues Phe43 and Arg59 make important interactions with gp120. Small molecule analogues were made to mimic the crucial features of these residues. The analogues were assayed using a cellular 'FIGS' assay to measure inhibition of cell fusion and caused some inhibition. (C) 2004 Elsevier Ltd. All rights reserved.",

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AU - Boussard, Cyrille

AU - Klimkait, Thomas

AU - Mahmood, Naheed

AU - Pritchard, Martin

AU - Gilbert, Ian H.

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AB - This paper describes an approach to prevent HIV-cell fusion by disrupting the interaction between HIV protein gp120 and CD4 receptor. The CD4 residues Phe43 and Arg59 make important interactions with gp120. Small molecule analogues were made to mimic the crucial features of these residues. The analogues were assayed using a cellular 'FIGS' assay to measure inhibition of cell fusion and caused some inhibition. (C) 2004 Elsevier Ltd. All rights reserved.

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JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

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Design, synthesis and evaluation of potential inhibitors of HIV gp120-CD4 interactions

Abstract

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