Desmoglein 1 deficiency results in severe dermatitis, multiple allergies and metabolic wasting

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• Finished

  Dermatology and Genetic Medicine (Strategic Grant) (Joint with Kings College London)

  Barton, G. (Investigator), Campbell, P. (Investigator), Hickerson, R. (Investigator), Leigh, I. (Investigator), McLean, I. (Investigator) & Wyatt, P. (Investigator)

  1/08/12 → 30/04/19

  Project: Research

  • Atopic Dermatitis 100%
  • Palmoplantar Keratoderma 38%
  • Gain-of-function mutation 33%
  • Filaggrin 32%
  • Disease 29%

• Human and Mouse Genetics Studies of Filaggrin-Related Proteins in Eczema and Allergy (Joint with Trinity College Dublin)

  Barton, G. (Investigator) & McLean, I. (Investigator)

  1/10/10 → 28/02/14

  Project: Research

  • Atopic Dermatitis 100%
  • Filaggrin 43%
  • Loss of Function Mutation 36%
  • Gain-of-function mutation 34%
  • Mutation in the Filaggrin Gene 27%

• Aref#d: 22163. The Establishment of a Large Case Collection of Childhood Atopic Dermatitis: A Resource for Gemetoc Research (Joint with Trinity College Dublin)

  McLean, I. (Investigator)

  1/03/10 → 28/02/14

  Project: Research

  • Atopic Dermatitis 100%
  • Filaggrin 42%
  • Epidermis 33%
  • Gain-of-function mutation 27%
  • Loss of Function Mutation 24%