Detection of cytochrome P450 mRNA transcripts in prostate samples by RT-PCR

N Finnström, C Bjelfman, T. G. Söderström, G. Smith, L Egevad, B J Norlén, C. R. Wolf, A Rane

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    66 Citations (Scopus)

    Abstract

    The expression of cytochrome P450 (CYP)-dependent mono-oxygenases in the prostate is important, as it will determine the rate of activation of potential carcinogens as well as the metabolism of hormones with implications in diseases of the prostate. In addition, the levels of cytochromes P450 in prostatic tumours may well be determinants of the outcome of therapy involving P450 substrates such as anti-androgens.
    Original languageEnglish
    Pages (from-to)880-886
    Number of pages7
    JournalEuropean Journal of Clinical Investigation
    Volume31
    Issue number10
    DOIs
    Publication statusPublished - 2001

    Keywords

    • Cytochrome P450
    • Gene expression
    • prostate
    • multiplex
    • reverse transcriptase PCR

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