Detection of cytochrome P450 mRNA transcripts in prostate samples by RT-PCR

N Finnström; C Bjelfman; T. G. Söderström; G. Smith; L Egevad; B J Norlén; C. R. Wolf; A Rane

doi:10.1046/j.1365-2362.2001.00893.x

Detection of cytochrome P450 mRNA transcripts in prostate samples by RT-PCR

N Finnström, C Bjelfman, T. G. Söderström, G. Smith, L Egevad, B J Norlén, C. R. Wolf, A Rane

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Abstract

The expression of cytochrome P450 (CYP)-dependent mono-oxygenases in the prostate is important, as it will determine the rate of activation of potential carcinogens as well as the metabolism of hormones with implications in diseases of the prostate. In addition, the levels of cytochromes P450 in prostatic tumours may well be determinants of the outcome of therapy involving P450 substrates such as anti-androgens.

Original language	English
Pages (from-to)	880-886
Number of pages	7
Journal	European Journal of Clinical Investigation
Volume	31
Issue number	10
DOIs	https://doi.org/10.1046/j.1365-2362.2001.00893.x
Publication status	Published - 2001

Keywords

Cytochrome P450
Gene expression
prostate
multiplex
reverse transcriptase PCR

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10.1046/j.1365-2362.2001.00893.x

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title = "Detection of cytochrome P450 mRNA transcripts in prostate samples by RT-PCR",

abstract = "The expression of cytochrome P450 (CYP)-dependent mono-oxygenases in the prostate is important, as it will determine the rate of activation of potential carcinogens as well as the metabolism of hormones with implications in diseases of the prostate. In addition, the levels of cytochromes P450 in prostatic tumours may well be determinants of the outcome of therapy involving P450 substrates such as anti-androgens.",

keywords = "Cytochrome P450, Gene expression, prostate, multiplex, reverse transcriptase PCR",

author = "N Finnstr{\"o}m and C Bjelfman and S{\"o}derstr{\"o}m, {T. G.} and G. Smith and L Egevad and Norl{\'e}n, {B J} and Wolf, {C. R.} and A Rane",

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T1 - Detection of cytochrome P450 mRNA transcripts in prostate samples by RT-PCR

AU - Finnström, N

AU - Bjelfman, C

AU - Söderström, T. G.

AU - Smith, G.

AU - Egevad, L

AU - Norlén, B J

AU - Wolf, C. R.

AU - Rane, A

PY - 2001

Y1 - 2001

N2 - The expression of cytochrome P450 (CYP)-dependent mono-oxygenases in the prostate is important, as it will determine the rate of activation of potential carcinogens as well as the metabolism of hormones with implications in diseases of the prostate. In addition, the levels of cytochromes P450 in prostatic tumours may well be determinants of the outcome of therapy involving P450 substrates such as anti-androgens.

AB - The expression of cytochrome P450 (CYP)-dependent mono-oxygenases in the prostate is important, as it will determine the rate of activation of potential carcinogens as well as the metabolism of hormones with implications in diseases of the prostate. In addition, the levels of cytochromes P450 in prostatic tumours may well be determinants of the outcome of therapy involving P450 substrates such as anti-androgens.

KW - Cytochrome P450

KW - Gene expression

KW - prostate

KW - multiplex

KW - reverse transcriptase PCR

U2 - 10.1046/j.1365-2362.2001.00893.x

DO - 10.1046/j.1365-2362.2001.00893.x

M3 - Article

C2 - 11737226

SN - 0014-2972

VL - 31

SP - 880

EP - 886

JO - European Journal of Clinical Investigation

JF - European Journal of Clinical Investigation

IS - 10

ER -

Detection of cytochrome P450 mRNA transcripts in prostate samples by RT-PCR

Abstract

Keywords

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