TY - JOUR
T1 - Detection of Fusobacterium in oral and head and neck cancer samples
T2 - A systematic review and meta-analysis
AU - Bronzato, Juliana D.
AU - Bomfim, Rafael A.
AU - Edwards, David H.
AU - Crouch, Dorothy
AU - Hector, Mark P.
AU - Gomes, Brenda P. F. A.
N1 - Copyright © 2020 Elsevier Ltd. All rights reserved.
PY - 2020/4
Y1 - 2020/4
N2 - Aims: This systematic review aimed to analyse: a) the presence and the abundance of Fusobacterium; b) the Fusobacterium species most often found, and c) the most common methods used for their identification in oral/head and neck cancer samples.Design: A protocol was registered on PROSPERO database. This review was conducted following PRISMA guidelines. Literature search was performed on five electronic biomedical databases, namely Pubmed, Scopus, Web of Science, Embase, and Cochrane from their start dates to 30 August 2018. Two reviewers independently assessed the eligibility for inclusion; extracted the data; and evaluated the risk of bias.Results: From 118 unique abstract records, 88 full-text articles were assessed for eligibility. According to inclusion and exclusion criteria, 17 publications were included in this review. Meta-analysis showed an increased prevalence of 6 % (95 % CI, 3–9) of Fusobacterium in tumour lesions than in non-tumour lesions (Fusobacterium prevalence of 16 % in tumour lesions and of 10 % in non-tumour lesions), and a 2.93 higher chance of Fusobacterium being present in tumour lesions (95 % CI, 1.47–5.81). The most common detection methods were based on molecular evidence (64.70 %) (95 % CI, 37.7–84.7). F. nucleatum was the most prevalent species (47.06 %) (95 % CI, 23.5–72).Conclusion: In conclusion, Fusobacterium is present and in higher abundance in oral/head and neck cancer samples when compared to non-cancer samples, suggesting that Fusobacterium may contribute to oral/head and neck cancer development.
AB - Aims: This systematic review aimed to analyse: a) the presence and the abundance of Fusobacterium; b) the Fusobacterium species most often found, and c) the most common methods used for their identification in oral/head and neck cancer samples.Design: A protocol was registered on PROSPERO database. This review was conducted following PRISMA guidelines. Literature search was performed on five electronic biomedical databases, namely Pubmed, Scopus, Web of Science, Embase, and Cochrane from their start dates to 30 August 2018. Two reviewers independently assessed the eligibility for inclusion; extracted the data; and evaluated the risk of bias.Results: From 118 unique abstract records, 88 full-text articles were assessed for eligibility. According to inclusion and exclusion criteria, 17 publications were included in this review. Meta-analysis showed an increased prevalence of 6 % (95 % CI, 3–9) of Fusobacterium in tumour lesions than in non-tumour lesions (Fusobacterium prevalence of 16 % in tumour lesions and of 10 % in non-tumour lesions), and a 2.93 higher chance of Fusobacterium being present in tumour lesions (95 % CI, 1.47–5.81). The most common detection methods were based on molecular evidence (64.70 %) (95 % CI, 37.7–84.7). F. nucleatum was the most prevalent species (47.06 %) (95 % CI, 23.5–72).Conclusion: In conclusion, Fusobacterium is present and in higher abundance in oral/head and neck cancer samples when compared to non-cancer samples, suggesting that Fusobacterium may contribute to oral/head and neck cancer development.
KW - Fusobacteria
KW - Fusobacterium
KW - Fusobacterium nucleatum
KW - Head and neck cancer
KW - Oral cancer
UR - http://www.scopus.com/inward/record.url?scp=85078798432&partnerID=8YFLogxK
U2 - 10.1016/j.archoralbio.2020.104669
DO - 10.1016/j.archoralbio.2020.104669
M3 - Review article
C2 - 32028171
AN - SCOPUS:85078798432
VL - 112
SP - 1
EP - 8
JO - Archives of Oral Biology
JF - Archives of Oral Biology
SN - 0003-9969
M1 - 104669
ER -